INT312102

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Context Info
Confidence 0.10
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.65
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (ALOX5, ALOX5AP) nucleus (ALOX5, ALOX5AP) cytosol (ALOX5)
small molecule metabolic process (ALOX5) oxidoreductase activity (ALOX5) endoplasmic reticulum (ALOX5AP)
ALOX5 (Homo sapiens)
ALOX5AP (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 17 98.96 Very High Very High Very High
Osteoarthritis 44 84.56 Quite High
cytokine 3 81.92 Quite High
cINOD 2 65.12 Quite High
rheumatoid arthritis 1 61.60 Quite High
Arthritis 2 40.96 Quite Low
metalloproteinase 7 23.20 Low Low
Inflammatory response 2 9.28 Low Low
licofelone 3 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 22 98.96 Very High Very High Very High
Osteoarthritis 48 84.56 Quite High
Adhesions 1 76.96 Quite High
Rheumatoid Arthritis 1 61.60 Quite High
Arthritis 2 40.96 Quite Low
Osteophyte 1 15.60 Low Low
Disease 3 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Functional 5-LOX requires binding to 5-lipoxygenase-activating protein (FLAP), which helps 5-LOX binding to AA at the nuclear membrane and enhances the efficiency of leukotriene synthesis [12]. 5-LOX gene expression at the transcriptional level is regulated by several transcription factors, such as smad3/4 and vitamin D receptors [13,14].
5-LOX Binding (binding) of FLAP
1) Confidence 0.10 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.65 Pain Relevance 0.36

General Comments

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