INT312105

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.30
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ELANE) extracellular region (ELANE) plasma membrane (PTGER2)
signal transducer activity (PTGER2) cytoplasm (ELANE)
Anatomy Link Frequency
liver 2
ELANE (Homo sapiens)
PTGER2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 169 99.00 Very High Very High Very High
Inflammation 57 87.96 High High
metalloproteinase 26 78.48 Quite High
alcohol 3 33.36 Quite Low
cytokine 9 5.00 Very Low Very Low Very Low
licofelone 9 5.00 Very Low Very Low Very Low
Inflammatory response 9 5.00 Very Low Very Low Very Low
COX-2 inhibitor 6 5.00 Very Low Very Low Very Low
cINOD 6 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 183 99.00 Very High Very High Very High
INFLAMMATION 75 87.96 High High
Disease 11 86.88 High High
Adhesions 27 50.00 Quite Low
Apoptosis 5 47.44 Quite Low
Death 7 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low
Leukemia 4 5.00 Very Low Very Low Very Low
Pathologic Processes 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data are in concordance with our previously reported COX-2 findings [20] and are supported by other investigations indicating that HNE is a potent inducer of COX-2 and PGE2 release in various cell lines, such as rat liver epithelial RL34 cells and the RAW264.7 macrophage cell line [29-31].
HNE Positive_regulation (inducer) of Localization (release) of PGE2 in liver
1) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.51 Pain Relevance 0.25
M HNE showed an increase in COX-2 protein expression and PGE2 release within 2 hours and plateaued at 8 hours of incubation, before declining at 16 hours and 24 hours (Figure 1a, b).
HNE Positive_regulation (increase) of Localization (release) of PGE2
2) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0 Pain Relevance 0
M HNE induced PGE2 release as well as COX-2 and mPGES-1 expression, which plateaued at 8 hours of incubation before declining at 16 and 24 hours, respectively.
HNE Positive_regulation (induced) of Localization (release) of PGE2
3) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.60 Pain Relevance 0.29
Our data revealed that HNE-modified Col II induced PGE2 release and COX-2 expression.
HNE-modified Positive_regulation (induced) of Localization (release) of PGE2
4) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991038 Disease Relevance 0.19 Pain Relevance 0.09

General Comments

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