INT312106

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Context Info
Confidence 0.31
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.06
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (EGR1, PTGES) isomerase activity (PTGES) nucleoplasm (EGR1)
signal transduction (PTGES) nucleus (EGR1) intracellular (EGR1)
EGR1 (Homo sapiens)
PTGES (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 2 99.84 Very High Very High Very High
Osteoarthritis 44 98.76 Very High Very High Very High
rheumatoid arthritis 1 98.08 Very High Very High Very High
Inflammation 17 90.48 High High
cytokine 3 76.08 Quite High
Arthritis 2 75.52 Quite High
metalloproteinase 7 57.76 Quite High
licofelone 3 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 22 99.72 Very High Very High Very High
Osteoarthritis 48 98.76 Very High Very High Very High
Rheumatoid Arthritis 1 98.08 Very High Very High Very High
Adhesions 1 85.92 High High
Arthritis 2 75.52 Quite High
Osteophyte 1 50.16 Quite High
Disease 3 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been shown that mPGES-1 expression is upregulated in animal models of rheumatoid arthritis and in patients suffering from OA [4,5] and is downregulated by anti-inflammatory drugs [6,7]. mPGES-1 expression is regulated by several transcription factors, such as early growth response-1 (Egr-1) and NF-?
Egr-1 Regulation (regulated) of Gene_expression (expression) of mPGES-1 associated with inflammation, cinod, rheumatoid arthritis and osteoarthritis
1) Confidence 0.31 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 1.06 Pain Relevance 0.64

General Comments

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