INT312107

Context Info Confidence 0.04 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

protein transporter activity (COX18) mitochondrion (COX18) peptidase activity (ELANE) extracellular region (ELANE) cytoplasm (ELANE)

ELANE (Homo sapiens) COX18 (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 44 20.40 Inflammation 17 5.00 metalloproteinase 7 5.00 cytokine 3 5.00 licofelone 3 5.00 COX-2 inhibitor 2 5.00 cINOD 2 5.00 Inflammatory response 2 5.00 Arthritis 2 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Osteoarthritis 48 50.00 Apoptosis 1 46.08 INFLAMMATION 22 5.00 Disease 3 5.00 Arthritis 2 5.00 Pain 1 5.00 Osteophyte 1 5.00 Necrosis 1 5.00 Adhesions 1 5.00 Pathologic Processes 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

M HNE showed an increase in COX-2 protein expression and PGE2 release within 2 hours and plateaued at 8 hours of incubation, before declining at 16 hours and 24 hours (Figure 1a, b).

HNE Positive_regulation (increase) of Gene_expression (expression) of COX-2 protein

1) Confidence 0.04 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0 Pain Relevance 0

General Comments

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