INT312112

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.82
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (ELANE, ALOX5) nuclear envelope (ALOX5) small molecule metabolic process (ALOX5)
cytosol (ALOX5) peptidase activity (ELANE) extracellular region (ELANE)
ELANE (Homo sapiens)
ALOX5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 88 92.68 High High
Inflammatory response 4 87.28 High High
Inflammatory mediators 2 82.00 Quite High
Arthritis 4 74.80 Quite High
Pain 2 63.76 Quite High
cINOD 4 59.60 Quite High
COX-2 inhibitor 4 34.72 Quite Low
Inflammation 34 18.40 Low Low
metalloproteinase 14 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 96 92.68 High High
INFLAMMATION 44 87.28 High High
Arthritis 4 74.80 Quite High
Pain 2 63.76 Quite High
Disease 6 5.00 Very Low Very Low Very Low
Osteophyte 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
Pathologic Processes 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data indicate that HNE regulates 5-LOX mRNA expression at the transcriptional level.


HNE Regulation (regulates) of Transcription (expression) of 5-LOX
1) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.29 Pain Relevance 0.15
The combination of naproxen with HNE, however, had no additive effect on 5-LOX mRNA expression.
HNE Neg (no) Regulation (effect) of Transcription (expression) of 5-LOX
2) Confidence 0.04 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.52 Pain Relevance 0.32

General Comments

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