INT312118

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Context Info
Confidence 0.22
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.92
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (ELANE, PTGES) isomerase activity (PTGES) signal transduction (PTGES)
peptidase activity (ELANE) extracellular region (ELANE)
Anatomy Link Frequency
chondrocytes 2
ELANE (Homo sapiens)
PTGES (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 88 98.40 Very High Very High Very High
Inflammation 34 97.24 Very High Very High Very High
metalloproteinase 14 89.20 High High
alcohol 2 77.76 Quite High
cytokine 6 42.88 Quite Low
licofelone 6 5.00 Very Low Very Low Very Low
COX-2 inhibitor 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 96 98.40 Very High Very High Very High
Disease 6 97.60 Very High Very High Very High
INFLAMMATION 44 97.24 Very High Very High Very High
Arthritis 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Osteophyte 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
Pathologic Processes 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since mPGES-1 regulation by HNE has not yet been reported, we extended our investigation to determine whether changes in mRNA levels may be ascribed to alterations in promoter activity by transiently transfecting chondrocytes with human mPGES-1 promoter-luciferase reporter genes.
HNE Regulation (regulation) of mPGES-1 in chondrocytes
1) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.28 Pain Relevance 0.18
In the present study, we investigated the effects of HNE on COX-2/mPGES-1 and 5-LOX pathways regulation in human OA chondrocytes.
HNE Spec (investigated) Regulation (effects) of mPGES-1 in chondrocytes associated with osteoarthritis
2) Confidence 0.19 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.64 Pain Relevance 0.32

General Comments

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