INT312119

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Context Info
Confidence 0.18
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.74
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (ELANE, PTGES) isomerase activity (PTGES) signal transduction (PTGES)
peptidase activity (ELANE) extracellular region (ELANE)
Anatomy Link Frequency
chondrocytes 2
ELANE (Homo sapiens)
PTGES (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 88 99.00 Very High Very High Very High
Inflammation 34 86.52 High High
COX-2 inhibitor 4 79.64 Quite High
metalloproteinase 14 78.48 Quite High
alcohol 2 10.96 Low Low
cytokine 6 5.00 Very Low Very Low Very Low
licofelone 6 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 96 99.00 Very High Very High Very High
Disease 6 86.88 High High
INFLAMMATION 44 86.52 High High
Arthritis 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Osteophyte 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
Pathologic Processes 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
M HNE induced PGE2 release as well as COX-2 and mPGES-1 expression, which plateaued at 8 hours of incubation before declining at 16 and 24 hours, respectively.
HNE Positive_regulation (induced) of Gene_expression (expression) of mPGES-1
1) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.60 Pain Relevance 0.29
M HNE to cultured chondrocytes induced PGE2 release as well as COX-2 and mPGES-1 expression at the protein and mRNA levels, with a plateau reached respectively at 8 and 16 hours of incubation, followed by a subsequent decline.
HNE Positive_regulation (induced) of Gene_expression (expression) of mPGES-1 in chondrocytes
2) Confidence 0.17 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2875653 Disease Relevance 0.14 Pain Relevance 0.04

General Comments

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