INT312122

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.65
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (ELANE, COL2A1) cytoplasm (ELANE, COL2A1) extracellular space (COL2A1)
peptidase activity (ELANE)
Anatomy Link Frequency
cleavage 2
ELANE (Homo sapiens)
COL2A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 7 100.00 Very High Very High Very High
Inflammatory response 2 93.28 High High
Osteoarthritis 44 92.64 High High
Inflammation 17 57.88 Quite High
cytokine 3 40.84 Quite Low
cINOD 2 24.04 Low Low
rheumatoid arthritis 1 20.52 Low Low
licofelone 3 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 22 93.28 High High
Osteoarthritis 48 92.64 High High
Pathologic Processes 1 65.04 Quite High
Adhesions 1 35.88 Quite Low
Rheumatoid Arthritis 1 20.52 Low Low
Disease 3 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Osteophyte 1 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By binding to proteins, HNE activates MMP-13 and increases the susceptibility of type II collagen to proteolytic cleavage by MMP-13 [18].
HNE Positive_regulation (increases) of Protein_catabolism (proteolytic) of type II collagen in cleavage associated with metalloproteinase
1) Confidence 0.05 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.65 Pain Relevance 0.39

General Comments

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