INT312123

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.74
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (ELANE, ALOX5) nuclear envelope (ALOX5) small molecule metabolic process (ALOX5)
cytosol (ALOX5) peptidase activity (ELANE) extracellular region (ELANE)
Anatomy Link Frequency
chondrocytes 2
ELANE (Homo sapiens)
ALOX5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 132 94.92 High High
cytokine 9 56.32 Quite High
Inflammation 51 37.88 Quite Low
metalloproteinase 21 5.00 Very Low Very Low Very Low
licofelone 9 5.00 Very Low Very Low Very Low
COX-2 inhibitor 6 5.00 Very Low Very Low Very Low
cINOD 6 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 144 94.92 High High
INFLAMMATION 66 37.88 Quite Low
Disease 9 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Osteophyte 3 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Necrosis 3 5.00 Very Low Very Low Very Low
Adhesions 3 5.00 Very Low Very Low Very Low
Pathologic Processes 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To more accurately identify whether HNE induced 5-LOX at the transcription level, the 5-LOX promoter construct with luciferase gene reporter was transiently transfected into human OA chondrocytes, followed by stimulation with single addition of 10 ?
HNE Spec (whether) Positive_regulation (induced) of 5-LOX in chondrocytes associated with osteoarthritis
1) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.27 Pain Relevance 0.13
Our data indicated that 5-LOX and FLAP upregulation by HNE occurred, at least in part, at the transcription level, as determined by real-time quantitative RT-PCR and transient transfection experiments.
HNE Positive_regulation (upregulation) of 5-LOX
2) Confidence 0.07 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.17 Pain Relevance 0.11
Compared with unstimulated cells, HNE induced 5-LOX gene promoter activity in transfected chondrocytes. 5-LOX promoter activity increased significantly by 310% and 580% after 48 and 72 hours of incubation, respectively (P < 0.05) (Figure 5).
HNE Positive_regulation (induced) of 5-LOX in chondrocytes
3) Confidence 0.07 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.30 Pain Relevance 0.15

General Comments

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