INT312126

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Context Info
Confidence 0.20
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.25
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (ALOX5AP) peptidase activity (ELANE) extracellular region (ELANE)
endoplasmic reticulum (ALOX5AP) nucleus (ALOX5AP) enzyme binding (ALOX5AP)
ELANE (Homo sapiens)
ALOX5AP (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 88 89.84 High High
cytokine 6 55.92 Quite High
Inflammation 34 22.32 Low Low
metalloproteinase 14 5.00 Very Low Very Low Very Low
licofelone 6 5.00 Very Low Very Low Very Low
COX-2 inhibitor 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 96 89.84 High High
INFLAMMATION 44 22.32 Low Low
Disease 6 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Osteophyte 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
Pathologic Processes 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
FLAP activation by HNE was abolished by naproxen, which prevents PGE2 production.
HNE Positive_regulation (activation) of FLAP
1) Confidence 0.20 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.08 Pain Relevance 0.04
Our data indicated that 5-LOX and FLAP upregulation by HNE occurred, at least in part, at the transcription level, as determined by real-time quantitative RT-PCR and transient transfection experiments.
HNE Positive_regulation (upregulation) of FLAP
2) Confidence 0.15 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.17 Pain Relevance 0.11

General Comments

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