INT312127

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Context Info
Confidence 0.35
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.37
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (ALOX5AP) endoplasmic reticulum (ALOX5AP) nucleus (ALOX5AP)
enzyme binding (ALOX5AP)
Anatomy Link Frequency
chondrocytes 2
ALOX5AP (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 44 99.72 Very High Very High Very High
Inflammation 17 45.44 Quite Low
metalloproteinase 7 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
licofelone 3 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 48 99.72 Very High Very High Very High
INFLAMMATION 22 45.44 Quite Low
Disease 3 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Osteophyte 1 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low
Adhesions 1 5.00 Very Low Very Low Very Low
Pathologic Processes 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, these results indicate that single treatment with HNE in OA chondrocytes induced the shunt from the production of PGE2 to LTB4 through COX-2 downregulation and 5-LOX and FLAP upregulation.


Positive_regulation (induced) of Positive_regulation (upregulation) of FLAP in chondrocytes associated with osteoarthritis
1) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.37 Pain Relevance 0.19

General Comments

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