INT312131

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Context Info
Confidence 0.16
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.12
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ALOX5) nuclear envelope (ALOX5) small molecule metabolic process (ALOX5)
oxidoreductase activity (ALOX5) nucleus (ALOX5) cytoplasm (ALOX5)
ALOX5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 132 66.04 Quite High
cytokine 9 16.88 Low Low
Inflammatory response 6 14.48 Low Low
Inflammatory mediators 3 9.20 Low Low
Inflammation 51 5.00 Very Low Very Low Very Low
metalloproteinase 21 5.00 Very Low Very Low Very Low
licofelone 9 5.00 Very Low Very Low Very Low
COX-2 inhibitor 6 5.00 Very Low Very Low Very Low
cINOD 6 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 144 66.04 Quite High
INFLAMMATION 66 14.48 Low Low
Disease 9 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Osteophyte 3 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Necrosis 3 5.00 Very Low Very Low Very Low
Adhesions 3 5.00 Very Low Very Low Very Low
Pathologic Processes 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Heightened LTB4 production upon HNE stimulation occurred 48 hours after the beginning of stimulation, coinciding with the time at which the 5-LOX mRNA level was elevated, and FLAP gene expression remained high.
Positive_regulation (upon) of Transcription (level) of 5-LOX
1) Confidence 0.16 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.05 Pain Relevance 0.03
Heightened LTB4 production upon HNE stimulation occurred 48 hours after the beginning of stimulation, coinciding with the time at which the 5-LOX mRNA level was elevated, and FLAP gene expression remained high.
Positive_regulation (elevated) of Transcription (level) of 5-LOX
2) Confidence 0.16 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0 Pain Relevance 0
Incubation of cells with naproxen, however, caused a consistent increase of 5-LOX mRNA level by 330% and 570% of control values (P < 0.001) after 24 and 72 hours of incubation, respectively (Figure 6c, d).
Positive_regulation (increase) of Transcription (level) of 5-LOX
3) Confidence 0.15 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.07 Pain Relevance 0.03

General Comments

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