INT312137

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Context Info
Confidence 0.50
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.37
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (ALOX5AP) endoplasmic reticulum (ALOX5AP) nucleus (ALOX5AP)
enzyme binding (ALOX5AP)
Anatomy Link Frequency
chondrocytes 1
ALOX5AP (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 88 97.40 Very High Very High Very High
Inflammation 34 61.24 Quite High
Inflammatory response 4 16.56 Low Low
Inflammatory mediators 2 11.28 Low Low
cytokine 6 10.96 Low Low
metalloproteinase 14 5.00 Very Low Very Low Very Low
licofelone 6 5.00 Very Low Very Low Very Low
COX-2 inhibitor 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 96 97.40 Very High Very High Very High
INFLAMMATION 44 61.24 Quite High
Disease 6 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Osteophyte 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
Pathologic Processes 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Figure 4b, c, our data disclosed that both FLAP and 5-LOX mRNA expression rose significantly but differentially after incubation in human OA chondrocytes.
Transcription (expression) of FLAP in chondrocytes associated with osteoarthritis
1) Confidence 0.50 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.37 Pain Relevance 0.18
Heightened LTB4 production upon HNE stimulation occurred 48 hours after the beginning of stimulation, coinciding with the time at which the 5-LOX mRNA level was elevated, and FLAP gene expression remained high.
Transcription (expression) of FLAP
2) Confidence 0.49 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0 Pain Relevance 0

General Comments

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