INT312212

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Context Info
Confidence 0.16
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.46
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (ADAM12, INPP5K) plasma membrane (ADAM12, INPP5K) mitochondrion (ADAM12)
endoplasmic reticulum (INPP5K) cytoplasm (INPP5K) cytosol (INPP5K)
ADAM12 (Homo sapiens)
INPP5K (Homo sapiens)
Pain Link Frequency Relevance Heat
Bioavailability 2 93.92 High High
Osteoarthritis 5 72.56 Quite High
metalloproteinase 3 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 11 97.84 Very High Very High Very High
Disease Progression 1 79.96 Quite High
Osteoarthritis 7 72.56 Quite High
Obesity 3 5.00 Very Low Very Low Very Low
Hypertrophy 2 5.00 Very Low Very Low Very Low
Osteoporosis 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Fibrosis 1 5.00 Very Low Very Low Very Low
Osteophyte 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This finding coupled with our observations that PPS promoted MPC proliferation, chondrogenesis, adipogenic differentiation while decreasing osteogenesis, and apoptosis leads us to suggest that some of these events could be mediated by the increased proteolysis of IGFBP-3 by ADAM-12 due to its interaction with PPS.
ADAM-12 Binding (interaction) of PPS associated with apoptosis
1) Confidence 0.16 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875662 Disease Relevance 0.46 Pain Relevance 0.11

General Comments

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