INT312223

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.10
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (INPP5K) extracellular region (COL10A1) endoplasmic reticulum (INPP5K)
plasma membrane (INPP5K) nucleus (INPP5K) cytoplasm (INPP5K)
Anatomy Link Frequency
chondrocyte 2
INPP5K (Homo sapiens)
COL10A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 5 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 2 100.00 Very High Very High Very High
Osteoporosis 2 23.20 Low Low
Obesity 3 14.04 Low Low
Apoptosis 11 5.00 Very Low Very Low Very Low
Osteoarthritis 7 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Fibrosis 1 5.00 Very Low Very Low Very Low
Osteophyte 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, MPC expression of gene markers for chondrocyte hypertrophy and osteogenesis, type X collagen and the key transcription factor for bone formation, RUNX2, were markedly downregulated by PPS at concentrations that induced the strongest MPC chondrogenic differentiation.
PPS Negative_regulation (downregulated) of Gene_expression (expression) of type X collagen in chondrocyte associated with hypertrophy
1) Confidence 0.04 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875662 Disease Relevance 0.10 Pain Relevance 0

General Comments

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