INT312242

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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.69
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGFBP5) extracellular region (IGFBP5)
IGFBP5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bioavailability 3 96.36 Very High Very High Very High
metalloproteinase 4 88.56 High High
Osteoarthritis 5 78.96 Quite High
Somatostatin 4 46.48 Quite Low
imagery 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 17 99.64 Very High Very High Very High
Pituitary Cancer 39 80.76 Quite High
Osteoarthritis 7 78.96 Quite High
Cancer 22 67.00 Quite High
Disease Progression 1 64.56 Quite High
Thyroid Neoplasm 1 47.88 Quite Low
Adenoma 7 5.00 Very Low Very Low Very Low
Acromegaly 5 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Obesity 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both IGFBP-3 and IGFBP-5 are degraded by the disintegrin metalloprotease, ADAM-12 (meltrin-?)
IGFBP-5 Binding (Both) of
1) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875662 Disease Relevance 0.24 Pain Relevance 0.08
Up to 90% of circulating IGF-I and IGF-II are carried by binding to either IGFBP-3 or IGFBP-5.
IGFBP-5 Binding (binding) of
2) Confidence 0.07 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3017030 Disease Relevance 0.45 Pain Relevance 0.09

General Comments

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