INT31227

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Context Info
Confidence 0.48
First Reported 1981
Last Reported 2008
Negated 1
Speculated 6
Reported most in Body
Documents 28
Total Number 34
Disease Relevance 4.86
Pain Relevance 5.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (GCG) signal transduction (GCG) extracellular space (GCG)
small molecule metabolic process (GCG) extracellular region (GCG) plasma membrane (GCG)
Anatomy Link Frequency
plasma 6
neuronal 2
B-cell 2
pore 2
GCG (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 18 100.00 Very High Very High Very High
Clonidine 16 100.00 Very High Very High Very High
opiate 4 99.84 Very High Very High Very High
Somatostatin 70 99.54 Very High Very High Very High
agonist 23 99.52 Very High Very High Very High
gABA 115 99.18 Very High Very High Very High
antagonist 184 99.12 Very High Very High Very High
Enkephalin 2 96.44 Very High Very High Very High
Action potential 184 94.68 High High
Opioid 6 94.60 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 389 99.68 Very High Very High Very High
Hypoglycemia 363 99.68 Very High Very High Very High
Disease 10 87.36 High High
Insulin Resistance 6 84.72 Quite High
Aging 1 77.60 Quite High
Genetic Predisposition To Disease 1 77.04 Quite High
Obesity 4 75.12 Quite High
Impaired Glucose Tolerance 47 71.48 Quite High
Cognitive Disorder 49 50.00 Quite Low
Pressure And Volume Under Development 2 45.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
cells, and that any change in glucagon release was therefore secondary to altered ?
Regulation (change) of Localization (release) of glucagon
1) Confidence 0.48 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1868042 Disease Relevance 0 Pain Relevance 0.17
Previous human studies have employed pharmacological KATP channel antagonists [23,24] or agonists [25,26] to examine the regulation of glucagon release in vivo.
Spec (examine) Regulation (regulation) of Localization (release) of glucagon associated with antagonist and agonist
2) Confidence 0.48 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1868042 Disease Relevance 0 Pain Relevance 0.18
The importance of the human KATP channel pathway for glucagon release is nicely highlighted by a study investigating the effects of the common Glu23Lys (E23K) polymorphism of the Kir6.2 subunit of the KATP channel on insulin and glucagon secretion in non-diabetic human patients [29].
Spec (investigating) Regulation (effects) of Localization (secretion) of glucagon associated with diabetes mellitus
3) Confidence 0.48 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1868042 Disease Relevance 0.10 Pain Relevance 0.10
GH and glucose increased but glucagon secretion remained unchanged.
Neg (unchanged) Regulation (unchanged) of Localization (secretion) of glucagon
4) Confidence 0.45 Published 1981 Journal Horm. Metab. Res. Section Abstract Doc Link 7308974 Disease Relevance 0 Pain Relevance 0.36
These data indicate that in man clonidine-induced GH secretion is not mediated by a stimulatory effect of clonidine on glucagon secretion and that alpha-adrenergic mechanisms have little role in the regulation of basal glucagon secretion.
Regulation (regulation) of Localization (secretion) of glucagon associated with clonidine
5) Confidence 0.45 Published 1981 Journal Horm. Metab. Res. Section Abstract Doc Link 7308974 Disease Relevance 0 Pain Relevance 0.36
Effect of clonidine on growth hormone and glucagon secretion.
Regulation (Effect) of Localization (secretion) of glucagon associated with clonidine
6) Confidence 0.45 Published 1981 Journal Horm. Metab. Res. Section Title Doc Link 7308974 Disease Relevance 0 Pain Relevance 0.38
Since data in the literature are rather controversial, we examined the effects of different doses of naloxone on insulin and glucagon secretion in 21 healthy nonobese volunteers (6 women and 15 men) by measuring the variations of insulin and glucagon plasma levels following a 5-g i.v. glucose load before and during a 30-min naloxone infusion.
Spec (examined) Regulation (effects) of Localization (secretion) of glucagon in plasma associated with narcan
7) Confidence 0.39 Published 1985 Journal Acta Diabetol Lat Section Abstract Doc Link 3890450 Disease Relevance 0 Pain Relevance 0.44
Primary role of glucagon release in the effect of beta-endorphin on glucose homeostasis in normal man.
Regulation (role) of Localization (release) of glucagon
8) Confidence 0.38 Published 1987 Journal Acta Endocrinol. Section Title Doc Link 2885994 Disease Relevance 0 Pain Relevance 0.14
Thus, although the present data do not entirely rule out these pathways as modulators of glucagon secretion, glucose is clearly able to suppress glucagon secretion independently of these.

?

Regulation (modulators) of Localization (secretion) of glucagon
9) Confidence 0.35 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1868042 Disease Relevance 0 Pain Relevance 0.21
cells is suggested to be a potential paracrine regulator of glucagon secretion.
Regulation (regulator) of Localization (secretion) of glucagon
10) Confidence 0.35 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1868042 Disease Relevance 0 Pain Relevance 0.29
Rodent and human glucagon secretion is regulated by an ?
Regulation (regulated) of Localization (secretion) of glucagon
11) Confidence 0.35 Published 2007 Journal PLoS Biology Section Abstract Doc Link PMC1868042 Disease Relevance 0.06 Pain Relevance 0.12
M diazoxide, the concentration at which an effect on glucagon release is first seen, then the effect will be very difficult to detect with electrophysiology, perhaps explaining why some studies have failed to detect a functional effect of the polymorphism (reviewed in [57]).
Regulation (effect) of Localization (release) of glucagon
12) Confidence 0.35 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1868042 Disease Relevance 0.20 Pain Relevance 0.03
Our data establish that KATP channel modulation has dramatic and direct effects on glucagon secretion and Ca2+ signalling in human ?
Regulation (effects) of Localization (secretion) of glucagon
13) Confidence 0.35 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1868042 Disease Relevance 0.06 Pain Relevance 0.16
-cell KATP channels as regulators of glucagon secretion, we studied islets from Kir6.2Y12X mice, which posses a Tyr12STOP mutation in the Kcnj11 gene, leading to premature termination of the KATP channel pore-forming subunit [48].
Regulation (regulators) of Localization (secretion) of glucagon in pore
14) Confidence 0.35 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1868042 Disease Relevance 0 Pain Relevance 0.04
We finally point out that the model we propose here for the control of glucagon secretion shares many features with what is known about the metabolic control of insulin secretion.
Regulation (control) of Localization (secretion) of glucagon
15) Confidence 0.35 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1868042 Disease Relevance 0.14 Pain Relevance 0.11
The regulation of insulin and glucagon secretion by opiates: a study with naloxone in healthy humans.
Regulation (regulation) of Localization (secretion) of glucagon associated with narcan and opiate
16) Confidence 0.28 Published 1985 Journal Acta Diabetol Lat Section Title Doc Link 3890450 Disease Relevance 0 Pain Relevance 0.72
These data indicate that in man clonidine-induced GH secretion is not mediated by a stimulatory effect of clonidine on glucagon secretion and that alpha-adrenergic mechanisms have little role in the regulation of basal glucagon secretion.
Regulation (effect) of Localization (secretion) of glucagon associated with clonidine
17) Confidence 0.27 Published 1981 Journal Horm. Metab. Res. Section Abstract Doc Link 7308974 Disease Relevance 0 Pain Relevance 0.36
However, the stimulatory effect of oral amino acids on glucagon release was modulated by plasma glucose concentration.
Regulation (effect) of Localization (release) of glucagon in plasma
18) Confidence 0.22 Published 2008 Journal Diabetes Section Body Doc Link PMC2453632 Disease Relevance 1.01 Pain Relevance 0
However, the stimulatory effect of oral amino acids on glucagon release was modulated by plasma glucose concentration.
Regulation (modulated) of Localization (release) of glucagon in plasma
19) Confidence 0.22 Published 2008 Journal Diabetes Section Body Doc Link PMC2453632 Disease Relevance 0.96 Pain Relevance 0
Studies on rat islets support an important role for paracrine signals as regulators of glucagon release [33,52,53], whereas the case for paracrine regulation of glucagon secretion from mouse and human ?
Regulation (role) of Localization (release) of glucagon
20) Confidence 0.21 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1868042 Disease Relevance 0 Pain Relevance 0.09

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