INT312287

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Context Info
Confidence 0.21
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.94
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Col9a1) cell adhesion (Col9a1) proteinaceous extracellular matrix (Col9a1)
structural molecule activity (Col9a1)
Anatomy Link Frequency
tendon 1
skeletal muscle 1
Col9a1 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 6 5.00 Very Low Very Low Very Low
Osteoarthritis 6 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
Action potential 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteochondrodysplasias 81 99.70 Very High Very High Very High
Muscle Disease 69 99.46 Very High Very High Very High
Tendinopathy 3 87.08 High High
Muscle Weakness 21 85.52 High High
Stress 15 72.32 Quite High
Disease 48 63.96 Quite High
Targeted Disruption 15 53.40 Quite High
Fatigue 6 39.28 Quite Low
Death 3 36.60 Quite Low
Osteoarthritis 21 10.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, it is tempting to speculate that the pathology in this case arises from an abnormal enthesis (the tendon to bone attachment site where type IX collagen is expressed).
Gene_expression (expressed) of type IX collagen in tendon
1) Confidence 0.21 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2875749 Disease Relevance 1.00 Pain Relevance 0
Interestingly, there is no evidence that type IX collagen is expressed in skeletal muscle as a fully functioning trimer [66, 67].
Gene_expression (expressed) of type IX collagen in skeletal muscle
2) Confidence 0.21 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2875749 Disease Relevance 0.98 Pain Relevance 0
This finding is very important as it may help explain the myopathy seen in MED patients with type IX collagen gene mutations, and more recently, with matrilin-3 mutations (Table 2).
Gene_expression (mutations) of type IX collagen gene associated with osteochondrodysplasias and muscle disease
3) Confidence 0.18 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2875749 Disease Relevance 0.96 Pain Relevance 0

General Comments

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