INT3123

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Context Info
Confidence 0.78
First Reported 1978
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 0.85
Pain Relevance 2.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Tyms) methyltransferase activity (Tyms) aging (Tyms)
mRNA binding (Tyms) nucleolus (Tyms) nucleus (Tyms)
Anatomy Link Frequency
neuronal 1
brain 1
sympathetic 1
Tyms (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 15 100.00 Very High Very High Very High
Catecholamine 1 99.98 Very High Very High Very High
tetrodotoxin 12 99.46 Very High Very High Very High
conotoxin 2 97.64 Very High Very High Very High
guanethidine 1 95.20 Very High Very High Very High
Calcium channel 5 94.64 High High
antagonist 2 94.52 High High
anesthesia 2 88.88 High High
agonist 2 83.92 Quite High
cva 1 81.68 Quite High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 4 98.64 Very High Very High Very High
Heart Rate Under Development 4 93.04 High High
Hypertension 2 91.56 High High
Hemorrhage 1 81.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is suggested that the edema depends on a sympathetic-adrenal discharge and that catecholamines released by TsTX act on alpha adrenergic receptors.
Localization (released) of TsTX in sympathetic associated with pressure and volume under development and catecholamine
1) Confidence 0.78 Published 1978 Journal Agents Actions Section Abstract Doc Link 636935 Disease Relevance 0.85 Pain Relevance 0.31
In this paper, the effect of the alpha-scorpion toxin tityustoxin (TsTX) in the release of gamma-[(3)H]aminobutyric acid ([(3)H]GABA) from rat brain cortical slices is described.
Localization (release) of TsTX in brain associated with gaba
2) Confidence 0.19 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12044644 Disease Relevance 0 Pain Relevance 0.45
Tetrodotoxin (TTX) completely inhibited the TsTX action on [(3)H]GABA release.
Localization (release) of TsTX associated with tetrodotoxin and gaba
3) Confidence 0.18 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12044644 Disease Relevance 0 Pain Relevance 0.56
The data suggest a neuronal origin for the release of [(3)H]GABA by TsTX.
Localization (release) of TsTX in neuronal associated with gaba
4) Confidence 0.15 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12044644 Disease Relevance 0 Pain Relevance 0.54
TsTX evokes [3H]ACh release in a concentration-dependent manner with a gradual increase up to saturation at concentrations of 500 nM.
Localization (release) of TsTX
5) Confidence 0.05 Published 2002 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 12585699 Disease Relevance 0 Pain Relevance 0.38
TsTx-V also stimulated insulin secretion at low glucose concentrations (2.8 mM) whereas the beta-toxin, Ts-gamma (gamma toxin), also obtained from Tityus serrulatus venom, significantly reduced TsTx-V-induced secretion at sub- and suprathreshold concentrations of glucose.
Localization (secretion) of Ts-gamma
6) Confidence 0.01 Published 2003 Journal Toxicon Section Abstract Doc Link 12875879 Disease Relevance 0 Pain Relevance 0.18
TsTx-V also stimulated insulin secretion at low glucose concentrations (2.8 mM) whereas the beta-toxin, Ts-gamma (gamma toxin), also obtained from Tityus serrulatus venom, significantly reduced TsTx-V-induced secretion at sub- and suprathreshold concentrations of glucose.
Localization (secretion) of Ts-gamma
7) Confidence 0.01 Published 2003 Journal Toxicon Section Abstract Doc Link 12875879 Disease Relevance 0 Pain Relevance 0.18

General Comments

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