INT312302

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.95
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Prss27) extracellular region (Prss27) cellular_component (Prss27)
Prss27 (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 5 77.08 Quite High
cytokine 10 53.84 Quite High
Nicotine 2 28.52 Quite Low
palliative 3 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myeloproliferative Disorder 102 100.00 Very High Very High Very High
Myelofibrosis 70 99.98 Very High Very High Very High
Myelodysplastic Syndromes 94 99.80 Very High Very High Very High
Chronic Myeloid Leukemia 9 97.52 Very High Very High Very High
Myeloid Leukemia 50 96.32 Very High Very High Very High
Apoptosis 42 92.76 High High
Disease 20 86.88 High High
Philadelphia Chromosome 2 78.64 Quite High
Multiple Myeloma 24 78.36 Quite High
Cancer 42 74.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The identification of an acquired somatic mutation in the JAK2 gene, resulting in a valine to phenylalanine substitution at position 617 (JAK2-V617F), has provided new insights into the pathogenesis of BCR-ABL1-negative MPN, which is found in most patients with polycythemia vera (PV) and in about 50% of patients with essential thrombocythemia (ET) and PMF [98, 99].
Gene_expression (found) of MPN associated with myeloproliferative disorder, myelodysplastic syndromes and myelofibrosis
1) Confidence 0.02 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2875768 Disease Relevance 1.38 Pain Relevance 0.16
PV, ET, and PMF make up the non-leukemic MPN.
Gene_expression (make) of MPN associated with myeloproliferative disorder, myelodysplastic syndromes and myelofibrosis
2) Confidence 0.02 Published 2010 Journal Invest New Drugs Section Body Doc Link PMC3003795 Disease Relevance 1.72 Pain Relevance 0.03
MPN and HDAC inhibitors
Gene_expression (MPN) of MPN associated with myeloproliferative disorder
3) Confidence 0.01 Published 2010 Journal Invest New Drugs Section Body Doc Link PMC3003795 Disease Relevance 0.85 Pain Relevance 0

General Comments

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