INT31231

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Context Info
Confidence 0.96
First Reported 1987
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.44
Pain Relevance 2.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MAOA) small molecule metabolic process (MAOA) oxidoreductase activity (MAOA)
Anatomy Link Frequency
brain 1
MAOA (Homo sapiens)
Pain Link Frequency Relevance Heat
monoamine 17 100.00 Very High Very High Very High
Serotonin 37 99.96 Very High Very High Very High
Dopamine 10 99.96 Very High Very High Very High
Neurotransmitter 11 99.72 Very High Very High Very High
noradrenaline 2 99.28 Very High Very High Very High
Catechol-O-methyltransferase 9 94.20 High High
Pain 2 88.16 High High
Endep 1 87.44 High High
antidepressant 53 85.88 High High
Central nervous system 5 78.68 Quite High
Disease Link Frequency Relevance Heat
Weight Gain 12 96.96 Very High Very High Very High
Anxiety Disorder 215 94.64 High High
Congenital Anomalies 3 92.16 High High
Pulmonary Hypertension 85 91.52 High High
Cancer 5 89.96 High High
Pain 2 88.16 High High
Weight Loss 1 84.68 Quite High
Disease 22 83.52 Quite High
Cognitive Disorder 4 82.88 Quite High
Obesity 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Monoamine oxidase A (MAOA) is the X-linked gene responsible for deamination and subsequent degradation of several neurotransmitters and other amines.
Protein_catabolism (degradation) of MAOA associated with neurotransmitter and monoamine
1) Confidence 0.96 Published 2004 Journal Hum. Genet. Section Abstract Doc Link 15349769 Disease Relevance 0.17 Pain Relevance 0.19
Monoamine oxidase A (MAOA) is the X-linked gene responsible for deamination and subsequent degradation of several neurotransmitters and other amines.
Protein_catabolism (degradation) of Monoamine oxidase A associated with neurotransmitter and monoamine
2) Confidence 0.86 Published 2004 Journal Hum. Genet. Section Abstract Doc Link 15349769 Disease Relevance 0.17 Pain Relevance 0.19
Monoamine oxidase inhibitors, which slow the metabolic degradation of monoamines, including serotonin and norepinephrine, allow for increased levels of these neurotransmitters within the brain.
Protein_catabolism (degradation) of Monoamine oxidase in brain associated with neurotransmitter, serotonin and monoamine
3) Confidence 0.61 Published 1987 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 2886102 Disease Relevance 0.68 Pain Relevance 0.67
MAO-A is primarily responsible for degrading serotonin and norepinephrine, as well as exogenous monoamines such as tyramine.
Protein_catabolism (degrading) of MAO associated with serotonin and monoamine
4) Confidence 0.53 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656289 Disease Relevance 0.19 Pain Relevance 0.44
MAO-B is primarily responsible for degrading dopamine.
Protein_catabolism (degrading) of MAO associated with dopamine
5) Confidence 0.53 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656289 Disease Relevance 0.12 Pain Relevance 0.44
Monoamine oxidase A (MAOA) degrades amine neurotransmitters including serotonin.
Protein_catabolism (degrades) of MAOA associated with neurotransmitter, serotonin and monoamine
6) Confidence 0.26 Published 2006 Journal Respir Res Section Body Doc Link PMC1351173 Disease Relevance 0.51 Pain Relevance 0.15
MAOA is another important enzyme that degrades biogenic amines (noradrenaline, serotonin, and, to a lesser degree, dopamine).
Protein_catabolism (degrades) of MAOA associated with dopamine, noradrenaline and serotonin
7) Confidence 0.22 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687723 Disease Relevance 0.61 Pain Relevance 0.34

General Comments

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