INT312362

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Context Info
Confidence 0.56
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 4.48
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PBX1) nucleolus (PBX1) nucleus (PBX1)
DNA binding (PBX1) transcription factor binding (PBX1) cytoplasm (PBX1)
Anatomy Link Frequency
stellate cells 3
PBX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 66 98.72 Very High Very High Very High
cytokine 6 97.40 Very High Very High Very High
Bile 3 71.04 Quite High
Chronic pancreatitis 27 70.64 Quite High
fibrosis 6 49.08 Quite Low
chemokine 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 66 98.72 Very High Very High Very High
Adhesions 9 98.48 Very High Very High Very High
Cancer 138 98.00 Very High Very High Very High
Primary Sclerosing Cholangitis 93 94.56 High High
Leukemia 3 91.68 High High
Disease 45 88.04 High High
Pancreatic Cancer 33 87.12 High High
Adenocarcinoma 36 74.24 Quite High
Metastasis 24 72.80 Quite High
Cirrhosis 138 71.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the differences did not reach statistical significance, Pbx1 expression was also 98% higher (p = 0.107) in inflammation associated stellate cells as determined by qRT-PCR (Figure 10A).
Gene_expression (expression) of Pbx1 in stellate cells associated with inflammation
1) Confidence 0.56 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 1.27 Pain Relevance 0.28
PBX1 expression levels tend to be increased in inflammatory- vs. tumor- stellate cells.
Gene_expression (expression) of PBX1 in stellate cells associated with inflammation and cancer
2) Confidence 0.56 Published 2010 Journal Mol Cancer Section Abstract Doc Link PMC2876060 Disease Relevance 1.98 Pain Relevance 0.30
Similarly, the protein expression of Pbx1 was also 64% higher in stellate cells derived from inflammatory pathologies compared to that of tumor derived stellate cells (p = 0.70, Figure 10B).
Gene_expression (expression) of Pbx1 in stellate cells associated with inflammation and cancer
3) Confidence 0.56 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 1.23 Pain Relevance 0.28

General Comments

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