INT312363

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Context Info
Confidence 0.59
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.55
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (CELSR3) plasma membrane (CELSR3) signal transducer activity (CELSR3)
Anatomy Link Frequency
stellate cells 2
plasma 1
CELSR3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 66 98.08 Very High Very High Very High
Chronic pancreatitis 27 64.92 Quite High
Bile 3 17.08 Low Low
cytokine 6 5.00 Very Low Very Low Very Low
fibrosis 6 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 138 99.84 Very High Very High Very High
Primary Sclerosing Cholangitis 93 99.60 Very High Very High Very High
Adenocarcinoma 36 98.12 Very High Very High Very High
INFLAMMATION 66 98.08 Very High Very High Very High
Chronic Myeloid Leukemia 3 92.16 High High
Myelodysplastic Syndromes 3 90.84 High High
Myeloproliferative Disorder 3 89.80 High High
Malignant Neoplastic Disease 3 68.04 Quite High
Pancreatic Cancer 33 65.80 Quite High
Disease 45 65.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upregulation of CELSR3 in tumor PSC could also provide a potential druggable target since the protein encoded by this gene is located at the plasma membrane and has intriguing signaling capabilities [33].
Positive_regulation (Upregulation) of CELSR3 in plasma associated with cancer and primary sclerosing cholangitis
1) Confidence 0.59 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 1.15 Pain Relevance 0.09
For example, cadherin EGF LAG seven-pass G-type receptor 3 (CELSR3) was 3.04-fold upregulated in tumor associated stellate cells compared to inflammation associated stellate cells.
Positive_regulation (upregulated) of CELSR3 in stellate cells associated with inflammation and cancer
2) Confidence 0.45 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 1.20 Pain Relevance 0.15
For example, cadherin EGF LAG seven-pass G-type receptor 3 (CELSR3) was 3.04-fold upregulated in tumor associated stellate cells compared to inflammation associated stellate cells.
Positive_regulation (upregulated) of G-type receptor 3 in stellate cells associated with inflammation and cancer
3) Confidence 0.40 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 1.21 Pain Relevance 0.15

General Comments

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