INT312377

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Context Info
Confidence 0.72
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.38
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (DPP4) extracellular region (DPP4) cell adhesion (DPP4)
Golgi apparatus (DPP4) endoplasmic reticulum (DPP4) plasma membrane (DPP4)
Anatomy Link Frequency
body 1
DPP4 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 6 96.64 Very High Very High Very High
cytokine 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
bradykinin 3 5.00 Very Low Very Low Very Low
Enkephalin 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Renal Cancer 117 100.00 Very High Very High Very High
Cancer 189 99.44 Very High Very High Very High
Aggression 6 95.76 Very High Very High Very High
Solid Tumor 6 93.40 High High
Malignant Neoplastic Disease 15 83.44 Quite High
Stress 3 79.60 Quite High
Skin Cancer 3 74.28 Quite High
Metastasis 3 68.16 Quite High
Prostate Cancer 3 61.52 Quite High
Endometriosis (extended) 3 60.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study also demonstrates a different DPP IV and NEP protein and mRNA expression depending on tumor type.
Transcription (expression) of DPP IV associated with cancer
1) Confidence 0.72 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.93 Pain Relevance 0.05
DPP IV has been commonly described as a membrane-bound peptidase, but the expression and activity of soluble isoforms have been reported in body fluids and in cytosolic fractions [6,37,38].
Transcription (described) of DPP IV in body
2) Confidence 0.69 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.81 Pain Relevance 0
This work demonstrates a strong downregulation of DPP IV and NEP in the renal tumors, different protein and mRNA expression profiles, which depend on the tumor type, and a positive correlation between soluble DPP IV activity and aggressiveness in CCRCCs.
Transcription (expression) of DPP IV associated with cancer, aggression and renal cancer
3) Confidence 0.23 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 1.64 Pain Relevance 0

General Comments

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