INT312392

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.51
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (DRGX)
Anatomy Link Frequency
neurons 2
DRGX (Homo sapiens)
Pain Link Frequency Relevance Heat
dorsal root ganglion 31 100.00 Very High Very High Very High
Paroxysmal extreme pain disorder 32 90.76 High High
Pain 16 87.28 High High
burning pain 3 84.88 Quite High
sodium channel 9 50.00 Quite Low
Nav1.7 1 48.80 Quite Low
Action potential 10 44.08 Quite Low
tetrodotoxin 11 32.96 Quite Low
carbamazepine 1 25.28 Quite Low
addiction 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 33 100.00 Very High Very High Very High
Somatoform Disorder 32 90.76 High High
Erythermalgia 31 90.04 High High
Pain 19 87.28 High High
Increased Venous Pressure Under Development 7 77.68 Quite High
Syndrome 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low
Myoclonic Epilepsies 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We show that these two mutations, both within the DIII/S4-S5 linker of the channel, have differential effects on activation and inactivation, and demonstrate that both increase the excitability of DRG neurons.


Positive_regulation (increase) of Regulation (excitability) of DRG in neurons associated with dorsal root ganglion
1) Confidence 0.05 Published 2010 Journal Mol Pain Section Body Doc Link PMC2876140 Disease Relevance 1.51 Pain Relevance 0.94

General Comments

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