INT312549

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.72
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DAK) lyase activity (DAK)
Anatomy Link Frequency
brain 3
DAK (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 21 94.20 High High
depression 217 92.04 High High
Serotonin 46 89.40 High High
antidepressant 39 87.16 High High
medulla 3 78.24 Quite High
Eae 14 58.44 Quite High
cytokine 8 41.88 Quite Low
Inflammation 60 41.52 Quite Low
Neurotransmitter 3 27.60 Quite Low
Limbic system 3 21.40 Low Low
Disease Link Frequency Relevance Heat
Disease 136 99.44 Very High Very High Very High
Targeted Disruption 7 92.88 High High
Weight Gain 3 92.72 High High
Post-partum Depression 90 92.04 High High
Body Weight 1 90.56 High High
Suicidal Behaviour 30 83.76 Quite High
Cognitive Disorder 50 81.12 Quite High
Depression 172 77.24 Quite High
Urological Neuroanatomy 10 76.72 Quite High
Aggression 3 53.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These effects of decreased brain DHA interact with the postpartum state such that the number of neurobiological alterations in postpartum rats with decreased brain DHA is greater than in virgin females with decreased brain DHA, and the magnitude of some of the alterations appears to be greater in the postpartum state.
DHA Binding (interact) of in brain
1) Confidence 0.01 Published 2011 Journal Depression Research and Treatment Section Body Doc Link PMC2989696 Disease Relevance 0.25 Pain Relevance 0.17
This suggests that the decrease in hippocampal BDNF expression is related to brain DHA status specifically, not an interaction of brain DHA level and reproductive status.
DHA Neg (not) Binding (interaction) of in brain
2) Confidence 0.01 Published 2011 Journal Depression Research and Treatment Section Body Doc Link PMC2989696 Disease Relevance 0.25 Pain Relevance 0.03
No alterations in hippocampal 5-HT1A binding were observed in virgin females with decreased brain DHA indicating that this represents an interaction of decreased brain DHA content with the postpartum state.
DHA Binding (interaction) of in brain
3) Confidence 0.01 Published 2011 Journal Depression Research and Treatment Section Body Doc Link PMC2989696 Disease Relevance 0.35 Pain Relevance 0.36
DHA is associated with reduced AD risk [126, 127].
DHA Binding (associated) of associated with disease
4) Confidence 0.01 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2876259 Disease Relevance 0.87 Pain Relevance 0.03

General Comments

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