INT312604

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Context Info
Confidence 0.71
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.48
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

anatomical structure development (Lrp4) plasma membrane (Lrp4)
Anatomy Link Frequency
osteoblast 1
femur 1
Lrp4 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 2 86.80 High High
anesthesia 1 63.52 Quite High
antagonist 6 50.00 Quite Low
agonist 2 36.96 Quite Low
Serotonin 14 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
midbrain 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Osteoarthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 20 100.00 Very High Very High Very High
Disease 15 91.16 High High
Pain 2 86.80 High High
Congenital Anomalies 10 84.24 Quite High
Congenital Myasthenic Syndromes 22 83.08 Quite High
Cancer 8 77.92 Quite High
Syndrome 9 68.04 Quite High
Retina Disease 2 65.44 Quite High
Bone Cancer 12 5.00 Very Low Very Low Very Low
Fracture Healing 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, it has recently been shown that LRP4, which is expressed in bone and cultured osteoblasts, binds Dkk1 and sclerostin in vitro and that Lrp4-deficient mice revealed shortened total femur length, reduced cortical femoral perimeter, reduced total femur bone mineral content (BMC), and bone mineral density (BMD) [58].
Gene_expression (expressed) of LRP4 in femur
1) Confidence 0.71 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.63 Pain Relevance 0.06
Thus, Lrp4 is also an osteoblast-expressed Dkk1- and sclerostin-receptor with a physiological role in the regulation of bone growth and turnover.
Gene_expression (expressed) of Lrp4 in osteoblast associated with osteoporosis
2) Confidence 0.62 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.53 Pain Relevance 0.09
Thus, the abnormal function of the MuSK mutants can not be explained on the basis of an impaired interaction between agrin and MuSK through the co-receptor Lrp4.
Neg (not) Gene_expression (explained) of Lrp4
3) Confidence 0.29 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2876883 Disease Relevance 0.32 Pain Relevance 0.06

General Comments

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