INT312624

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Context Info
Confidence 0.61
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.90
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Agrn) extracellular space (Agrn) extracellular region (Agrn)
proteinaceous extracellular matrix (Agrn) plasma membrane organization (Agrn)
Anatomy Link Frequency
myotubes 1
Agrn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Action potential 3 21.44 Low Low
anesthesia 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Myasthenic Syndromes 66 94.88 High High
Respiratory Failure 6 71.76 Quite High
Cyanosis 3 40.88 Quite Low
Patent Ductus Arteriosus 3 38.80 Quite Low
Syndrome 9 10.16 Low Low
Disease 3 7.28 Low Low
Myasthenia Gravis 9 5.00 Very Low Very Low Very Low
Congenital Anomalies 6 5.00 Very Low Very Low Very Low
Muscle Weakness 6 5.00 Very Low Very Low Very Low
Frailty 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These mutations impair the expression and stability of MuSK, diminish agrin-dependent MuSK phosphorylation and AChR clustering, and fail to co-immunoprecipitate with Dok-7 but not with Lrp4 or Tid1.
Phosphorylation (phosphorylation) of agrin
1) Confidence 0.61 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2876883 Disease Relevance 0.38 Pain Relevance 0
Expression studies in MuSK deficient myotubes revealed that A727V, which is located within the catalytic loop of the enzyme, caused severe impairment of agrin-dependent MuSK phosphorylation, aggregation of acetylcholine receptors (AChRs) and interaction of MuSK with Dok-7, an essential intracellular binding protein of MuSK.
Phosphorylation (phosphorylation) of agrin in myotubes
2) Confidence 0.61 Published 2010 Journal Human Molecular Genetics Section Abstract Doc Link PMC2876883 Disease Relevance 0.26 Pain Relevance 0
In contrast, M605I, resulted in only moderate impairment of agrin-dependent MuSK phosphorylation, aggregation of AChRs and interaction of MuSK with Dok-7.
Phosphorylation (phosphorylation) of agrin
3) Confidence 0.61 Published 2010 Journal Human Molecular Genetics Section Abstract Doc Link PMC2876883 Disease Relevance 0.26 Pain Relevance 0

General Comments

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