INT312636

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Context Info
Confidence 0.21
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.32
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Musk, Lrp4) anatomical structure development (Lrp4) signal transduction (Musk)
kinase activity (Musk)
Musk (Mus musculus)
Lrp4 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 1 63.52 Quite High
Action potential 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 2 83.08 Quite High
Congenital Myasthenic Syndromes 22 81.92 Quite High
Myasthenia Gravis 3 5.00 Very Low Very Low Very Low
Syndrome 3 5.00 Very Low Very Low Very Low
Respiratory Failure 2 5.00 Very Low Very Low Very Low
Muscle Weakness 2 5.00 Very Low Very Low Very Low
Frailty 1 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 1 5.00 Very Low Very Low Very Low
Cognitive Disorder 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the abnormal function of the MuSK mutants can not be explained on the basis of an impaired interaction between agrin and MuSK through the co-receptor Lrp4.
Negative_regulation (impaired) of MuSK Neg (impaired) Binding (interaction) of Lrp4
1) Confidence 0.21 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2876883 Disease Relevance 0.32 Pain Relevance 0.06

General Comments

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