INT312646

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.38
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Agrn) transport (CHRNE) extracellular space (Agrn)
signal transduction (CHRNE) extracellular region (Agrn) proteinaceous extracellular matrix (Agrn)
Agrn (Rattus norvegicus)
CHRNE (Homo sapiens)
Pain Link Frequency Relevance Heat
Action potential 1 22.16 Low Low
anesthesia 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Myasthenic Syndromes 22 94.88 High High
Respiratory Failure 2 71.76 Quite High
Cyanosis 1 41.60 Quite Low
Patent Ductus Arteriosus 1 39.52 Quite Low
Syndrome 3 10.16 Low Low
Disease 1 7.28 Low Low
Myasthenia Gravis 3 5.00 Very Low Very Low Very Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low
Muscle Weakness 2 5.00 Very Low Very Low Very Low
Frailty 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These mutations impair the expression and stability of MuSK, diminish agrin-dependent MuSK phosphorylation and AChR clustering, and fail to co-immunoprecipitate with Dok-7 but not with Lrp4 or Tid1.
agrin Positive_regulation (dependent) of Phosphorylation (phosphorylation) of AChR
1) Confidence 0.02 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2876883 Disease Relevance 0.38 Pain Relevance 0

General Comments

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