INT31268

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Context Info
Confidence 0.26
First Reported 1987
Last Reported 1993
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.82
Pain Relevance 1.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
sympathetic 1
Da2-19 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 9 100.00 Very High Very High Very High
agonist 21 99.48 Very High Very High Very High
antagonist 3 98.56 Very High Very High Very High
dopamine receptor 8 94.08 High High
Clonidine 1 75.28 Quite High
anesthesia 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Heart Rate Under Development 7 98.72 Very High Very High Very High
Hypertension 2 85.68 High High
Pressure Volume 2 Under Development 2 85.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results obtained with the DA2 antagonist metoclopramide (15 mg/kg ip) alone suggest that there is physiological activation of cardiovascular DA2 receptors in EC rats but not in NC rats.
Positive_regulation (activation) of DA2 associated with dopamine and antagonist
1) Confidence 0.26 Published 1993 Journal J. Appl. Physiol. Section Abstract Doc Link 8101519 Disease Relevance 0.49 Pain Relevance 0.72
In contrast, SK&F 89124 activates only the DA2 subtype.
Positive_regulation (activates) of DA2
2) Confidence 0.05 Published 1987 Journal Clin Exp Hypertens A Section Abstract Doc Link 2887313 Disease Relevance 0.14 Pain Relevance 0.45
The principal pharmacologic difference is enhanced bradycardia with the compounds having DA2 agonist activity, resulting from activation of neuroinhibitory DA2 receptors on cardiac sympathetic nerve terminals.
Positive_regulation (activation) of DA2 in sympathetic associated with heart rate under development and agonist
3) Confidence 0.05 Published 1987 Journal Clin Exp Hypertens A Section Abstract Doc Link 2887313 Disease Relevance 0.18 Pain Relevance 0.50

General Comments

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