INT312693

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Context Info
Confidence 0.34
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.33
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCR6, CCL20) extracellular space (CCL20) extracellular region (CCL20)
plasma membrane (CCR6) cell-cell signaling (CCL20) signal transducer activity (CCR6)
Anatomy Link Frequency
dendritic cells 1
synovium 1
CCR6 (Homo sapiens)
CCL20 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 26 96.96 Very High Very High Very High
chemokine 6 90.56 High High
Arthritis 81 78.96 Quite High
cytokine 14 72.20 Quite High
fibrosis 2 53.80 Quite High
metalloproteinase 2 37.84 Quite Low
Chronic pancreatitis 23 24.56 Low Low
antagonist 6 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Inflammatory marker 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 30 96.96 Very High Very High Very High
Cancer 17 91.28 High High
Leukemia 1 89.28 High High
Lymphatic System Cancer 1 88.40 High High
Skin Cancer 2 87.60 High High
Hepatocellular Cancer 1 86.80 High High
Reprotox - General 1 1 84.72 Quite High
Pancreatic Cancer 62 84.24 Quite High
Adenocarcinoma 2 82.48 Quite High
Rheumatoid Arthritis 75 78.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Only the G-protein coupled 7-transmembrane receptor CCR6, which is also expressed in human dendritic cells, shows a strong interaction with CCL20 [18].
CCR6 Binding (interaction) of CCL20 in dendritic cells
1) Confidence 0.34 Published 2010 Journal J Transl Med Section Body Doc Link PMC2877001 Disease Relevance 1.87 Pain Relevance 0.30
In contrast to non-specific influx, Th17 cells may preferentially migrate into the joint via CCR6 interaction with CCL20, which is strongly expressed in the synovium [35].
CCR6 Binding (interaction) of CCL20 in synovium
2) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.46 Pain Relevance 0.23

General Comments

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