INT3127

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Context Info
Confidence 0.68
First Reported 1978
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 38
Total Number 38
Disease Relevance 26.29
Pain Relevance 3.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (SRI) transport (SRI) plasma membrane (SRI)
intracellular (SRI) cytoplasm (SRI)
Anatomy Link Frequency
SCN 5
neurons 4
plasma 1
covering 1
Brain 1
SRI (Homo sapiens)
Pain Link Frequency Relevance Heat
sSRI 13 100.00 Very High Very High Very High
gABA 5 100.00 Very High Very High Very High
opioid receptor 7 99.88 Very High Very High Very High
Cannabinoid receptor 2 98.72 Very High Very High Very High
Neuropeptide 10 98.56 Very High Very High Very High
Serotonin 24 98.18 Very High Very High Very High
agonist 5 97.76 Very High Very High Very High
Cannabinoid 20 96.96 Very High Very High Very High
Enkephalin 6 96.56 Very High Very High Very High
ketamine 3 95.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Respiratory Failure 694 100.00 Very High Very High Very High
Impulse Control Disorders 118 100.00 Very High Very High Very High
Anxiety Disorder 221 99.92 Very High Very High Very High
Aging 42 99.78 Very High Very High Very High
Dementia 183 99.50 Very High Very High Very High
Volume Depletion And Dehydration 63 99.36 Very High Very High Very High
Disease 384 98.36 Very High Very High Very High
Filariasis 10 96.04 Very High Very High Very High
Lymphatic Filariasis 6 90.96 High High
Sleep Disorders 65 89.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Perhaps in the early stages of dementia, there is damage to the SCN that produces a decline in rhythmicity.
Gene_expression (produces) of SCN associated with dementia
1) Confidence 0.68 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413196 Disease Relevance 0.69 Pain Relevance 0.04
Edgar et al (1993) lesioned the SCN in squirrel monkeys and produced fragmented sleep/wake patterns similar to those seen in dementia.
Gene_expression (lesioned) of SCN associated with dementia
2) Confidence 0.59 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413196 Disease Relevance 0.71 Pain Relevance 0.07
The authors determined the rates of CN and SCN production during SNP infusion sufficient to maintain blood pressure at 80 per cent of baseline in the dog awake and during halothane anesthesia.
Gene_expression (production) of SCN in blood associated with anesthesia and halothane
3) Confidence 0.51 Published 1978 Journal Anesthesiology Section Abstract Doc Link 637333 Disease Relevance 0 Pain Relevance 0.27
-opioid receptors were identified in the hamster SCN, and the ?
Gene_expression (identified) of SCN associated with opioid receptor
4) Confidence 0.42 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004635 Disease Relevance 0 Pain Relevance 0.91
SRI-PW: SRI subdomain psychological wellbeing;
Gene_expression (wellbeing) of SRI associated with respiratory failure
5) Confidence 0.40 Published 2007 Journal Respir Res Section Body Doc Link PMC2222604 Disease Relevance 3.04 Pain Relevance 0
SRI-SF: SRI subdomain social functioning;
Gene_expression (functioning) of SRI associated with respiratory failure
6) Confidence 0.40 Published 2007 Journal Respir Res Section Body Doc Link PMC2222604 Disease Relevance 3.00 Pain Relevance 0
SRI-PW: SRI subdomain psychological wellbeing;
Gene_expression (wellbeing) of SRI-PW associated with respiratory failure
7) Confidence 0.40 Published 2007 Journal Respir Res Section Body Doc Link PMC2222604 Disease Relevance 3.05 Pain Relevance 0
SRI-PF: SRI subdomain physical functioning;
Gene_expression (functioning) of SRI associated with respiratory failure
8) Confidence 0.40 Published 2007 Journal Respir Res Section Body Doc Link PMC2222604 Disease Relevance 3.09 Pain Relevance 0
SRI-SF: SRI subdomain social functioning;
Gene_expression (functioning) of SRI associated with respiratory failure
9) Confidence 0.40 Published 2007 Journal Respir Res Section Body Doc Link PMC2222604 Disease Relevance 2.94 Pain Relevance 0
SRI-PF: SRI subdomain physical functioning;
Gene_expression (functioning) of SRI associated with respiratory failure
10) Confidence 0.40 Published 2007 Journal Respir Res Section Body Doc Link PMC2222604 Disease Relevance 3.15 Pain Relevance 0
The SRI questionnaire comprises 49 questions across 7 domains covering respiratory complaints (RC), physical functioning (PF), attendant symptoms and sleep (AS), social relationship (SR), anxiety (AX), psychological wellbeing (PW), and social functioning (SF).
Gene_expression (questionnaire) of SRI in covering associated with anxiety disorder and respiratory failure
11) Confidence 0.35 Published 2007 Journal Respir Res Section Body Doc Link PMC2222604 Disease Relevance 1.58 Pain Relevance 0
The functional disruption of the SCN is even observed in the early stages of AD.
Gene_expression (disruption) of SCN associated with disease
12) Confidence 0.25 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2939436 Disease Relevance 0.67 Pain Relevance 0.09
Functional disturbances of SCN circadian activity may start already around the age of 50, as evidenced by a decrease in vasopressin rhythmic function, in the expression of melatonin receptors in the SCN and in melatonin production compared to younger adults [14,16,43].
Gene_expression (expression) of SCN
13) Confidence 0.21 Published 2010 Journal BMC Med Section Body Doc Link PMC2933606 Disease Relevance 0.23 Pain Relevance 0.03
SLR: Sri Lanka rupee
Gene_expression (rupee) of Sri
14) Confidence 0.21 Published 2004 Journal Filaria J Section Body Doc Link PMC514715 Disease Relevance 0.59 Pain Relevance 0
SCN neurons, including those using GABA as a transmitter, and axons within the SCN, expressed CB1R immunoreactivity.
Gene_expression (expressed) of SCN in SCN associated with gaba
15) Confidence 0.13 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20668190 Disease Relevance 0 Pain Relevance 0.47
SCN neurons, including those using GABA as a transmitter, and axons within the SCN, expressed CB1R immunoreactivity.
Gene_expression (expressed) of SCN in SCN associated with gaba
16) Confidence 0.11 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20668190 Disease Relevance 0 Pain Relevance 0.47
The clear distinction between dehydration and rehydration processes shown here in the presence of SCN?
Gene_expression (presence) of SCN associated with volume depletion and dehydration
17) Confidence 0.11 Published 2007 Journal Blood Section Body Doc Link PMC1939906 Disease Relevance 0.38 Pain Relevance 0
could not be seen so distinctly in the absence of SCN?
Neg (absence) Gene_expression (absence) of SCN
18) Confidence 0.11 Published 2007 Journal Blood Section Body Doc Link PMC1939906 Disease Relevance 0.38 Pain Relevance 0
(not shown), indicating that prolonged exposure to 10 mM SCN?
Gene_expression (exposure) of SCN
19) Confidence 0.11 Published 2007 Journal Blood Section Body Doc Link PMC1939906 Disease Relevance 0.32 Pain Relevance 0
The phase-shifting effects of exercise on mammalian circadian rhythms are thought to be mediated by inputs to SCN neurons (these include serotonin [24], neuropeptide Y [25], and melatonin [13,26]) and ultimately lead to acute changes in SCN Per1 and Per2 expression [27].
Gene_expression (expression) of SCN in SCN associated with neuropeptide and serotonin
20) Confidence 0.09 Published 2003 Journal Genome Biol Section Body Doc Link PMC328450 Disease Relevance 0 Pain Relevance 0.10

General Comments

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