INT31270

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Context Info
Confidence 0.30
First Reported 1984
Last Reported 1995
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.20
Pain Relevance 4.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
DA neurons 2
neuronal 1
NAc 1
DA-1 1
LOC100366054 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 71 100.00 Very High Very High Very High
agonist 13 100.00 Very High Very High Very High
dopamine receptor 3 100.00 Very High Very High Very High
cocaine 24 99.92 Very High Very High Very High
anesthesia 3 98.78 Very High Very High Very High
Ventral tegmentum 12 98.28 Very High Very High Very High
Nucleus accumbens 10 98.00 Very High Very High Very High
midbrain 1 94.04 High High
antagonist 3 91.76 High High
local anesthetic 4 83.92 Quite High
Disease Link Frequency Relevance Heat
Heart Rate Under Development 1 89.04 High High
Hypotension 2 61.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with reserpine to deplete vesicular stores of DA significantly reduced the ability of intravenous cocaine to suppress A10 DA neuronal activity.
Negative_regulation (suppress) of A10 DA in neuronal associated with dopamine and cocaine
1) Confidence 0.30 Published 1988 Journal J. Neurosci. Section Abstract Doc Link 3339402 Disease Relevance 0 Pain Relevance 1.31
The present study was aimed to verify whether general anesthesia and/or other factors might contribute to the depolarization inactivation of A9 and A10 DA neurons.
Negative_regulation (inactivation) of A10 DA in DA neurons associated with dopamine and anesthesia
2) Confidence 0.30 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7869090 Disease Relevance 0 Pain Relevance 0.57
This effect was not observed with iontophoretically administered procaine iontophoresis of cocaine also significantly potentiated the inhibition of A10 DA activity caused by electrical stimulation of the nucleus accumbens (NAc).
Negative_regulation (inhibition) of A10 DA in NAc associated with nucleus accumbens, dopamine and cocaine
3) Confidence 0.22 Published 1988 Journal J. Neurosci. Section Abstract Doc Link 3339402 Disease Relevance 0 Pain Relevance 1.37
In conclusion, these results indicate that DA-1 and DA-2 dopamine receptor agonists can be easily discriminated on the basis of their cardiovascular profiles.
Negative_regulation (discriminated) of DA-1 in DA-1 associated with dopamine receptor and agonist
4) Confidence 0.14 Published 1987 Journal Clin Exp Hypertens A Section Abstract Doc Link 2887315 Disease Relevance 0.20 Pain Relevance 0.21
Thus, the ability of various agonists to inhibit the activity of A10 DA neurons was compared.
Negative_regulation (inhibit) of A10 DA in DA neurons associated with dopamine and agonist
5) Confidence 0.12 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6491980 Disease Relevance 0 Pain Relevance 0.77

General Comments

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