INT312733

Context Info Confidence 0.43 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.07 Pain Relevance 0.05

endoplasmic reticulum (UGT2B17)

UGT2B17 (Homo sapiens)

Pain Link Frequency Relevance Heat Bioavailability 1 97.04 cINOD 4 5.00 diclofenac 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Renal Disease 18 72.00 Disease 1 12.80 Obesity 11 5.00 Injury 8 5.00 Focal Segmental Glomerulosclerosis 5 5.00 Chronic Renal Failure 4 5.00 Pulmonary Disease 4 5.00 Acquired Immune Deficiency Syndrome Or Hiv Infection 3 5.00 Renal Failure 2 5.00 Keloid Scars 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A deficiency of the UGT2B17 enzyme decreases the rate of steroid deactivation and elimination, and owing to this, the bioavailability of steroids may be enhanced to a certain extent.

Negative_regulation (decreases) of Negative_regulation (deficiency) of UGT2B17 associated with bioavailability

1) Confidence 0.43 Published 2010 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2877023 Disease Relevance 0.07 Pain Relevance 0.05

General Comments

This test has worked.