INT312738

Context Info Confidence 0.45 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 4 Disease Relevance 1.04 Pain Relevance 0.94

endoplasmic reticulum (UGT2B17)

UGT2B17 (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 16 99.48 diclofenac 4 92.80 Pain 4 92.40 Bioavailability 4 5.00

Disease Link Frequency Relevance Heat Obesity 44 95.20 Renal Disease 72 93.24 Pain 4 92.40 INFLAMMATION 4 91.56 Proteinuria 8 86.76 Keloid Scars 8 84.52 Injury 32 83.96 Renal Failure 8 68.96 Focal Segmental Glomerulosclerosis 20 46.32 Urinary Tract Infection 4 18.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Following the paper by Schulze and colleagues [18] on the effect of UGT2B17 gene deletion polymorphism on doping tests, it is likely that this discovery is turned into practice and abused by athletes determined to use AAS.

Regulation (effect) of UGT2B17

1) Confidence 0.45 Published 2010 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2877023 Disease Relevance 0.07 Pain Relevance 0

As the hypothesis is based on the dysergistic effect of the UGT2B17 polymorphism and long term exposure to AAS, a single clinical trial approach does not present a feasible way to generate evidence to support or refute the hypothesis.

Regulation (effect) of UGT2B17

2) Confidence 0.45 Published 2010 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2877023 Disease Relevance 0.58 Pain Relevance 0

The inhibitory effect was also found to be dependent on the UGT2B17 genotype.

Regulation (dependent) of UGT2B17

3) Confidence 0.45 Published 2010 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2877023 Disease Relevance 0.23 Pain Relevance 0.46

Compared to UGT2B17, UGT2B15 was found to be more sensitive to both the NSAIDs, particularly ibuprofen.

Regulation (sensitive) of UGT2B17 associated with cinod

4) Confidence 0.12 Published 2010 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2877023 Disease Relevance 0.15 Pain Relevance 0.47

General Comments

This test has worked.