INT312743

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Context Info
Confidence 0.51
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.01
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gria1) endoplasmic reticulum (Gria1) plasma membrane (Gria1)
protein complex (Gria1)
Anatomy Link Frequency
amygdala 4
brain 2
hippocampus 2
Gria1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 156 99.32 Very High Very High Very High
amygdala 103 98.36 Very High Very High Very High
long-term potentiation 93 96.28 Very High Very High Very High
Glutamate receptor 6 61.28 Quite High
antagonist 15 52.32 Quite High
agonist 9 51.72 Quite High
GABAergic 12 51.36 Quite High
Glutamate 6 41.64 Quite Low
depression 20 5.00 Very Low Very Low Very Low
Locus ceruleus 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 226 100.00 Very High Very High Very High
Anxiety Disorder 27 92.08 High High
Cognitive Disorder 11 68.08 Quite High
Targeted Disruption 4 15.80 Low Low
Overactive Bladder 3 6.40 Low Low
Depression 20 5.00 Very Low Very Low Very Low
Decapitation 6 5.00 Very Low Very Low Very Low
Affective Disorder 6 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 3 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Namely, these effects occur because acute stress differentially modulates GluA1 AMPAR subunit phosphorylation, with decreased phosphorylation seen in the DH and mPFC and increased phosphorylation seen in the amygdala.
Regulation (modulates) of Phosphorylation (phosphorylation) of GluA1 in amygdala associated with stress, hippocampus and amygdala
1) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.51 Pain Relevance 0.59
We have previously reported that elevated platform stress does not lead to a general modulation of GluA1 phosphorylation in brain tissue sampled from the entire frontal cortices [35].
Regulation (modulation) of Phosphorylation (phosphorylation) of GluA1 in brain associated with stress
2) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.67 Pain Relevance 0.07
We observed opposite effects of stress on GluA1 phosphorylation in the mPFC and DH when compared to the amygdala and VH.
Regulation (effects) of Phosphorylation (phosphorylation) of GluA1 in amygdala associated with stress, hippocampus and amygdala
3) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.53 Pain Relevance 0.38
Specifically, norepinephrine application resulted in phosphorylation of the GluR1 sites Ser845 and Ser831 which facilitated the synaptic delivery of GluR1 in CA1 neurons in the hippocampus.
Regulation (resulted) of Phosphorylation (phosphorylation) of GluR1 in hippocampus associated with hippocampus
4) Confidence 0.15 Published 2010 Journal Mol Brain Section Body Doc Link PMC2877027 Disease Relevance 0.30 Pain Relevance 0.46

General Comments

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