INT312774

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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.30
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl4) extracellular region (Ccl4)
Anatomy Link Frequency
liver 4
Ccl4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 1 65.60 Quite High
cytokine 9 63.72 Quite High
Inflammation 28 63.32 Quite High
fibrosis 9 48.64 Quite Low
anesthesia 2 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Liver Disease 16 100.00 Very High Very High Very High
Cirrhosis 26 99.96 Very High Very High Very High
Disorder Of Lipid Metabolism 77 96.96 Very High Very High Very High
Disease 5 91.20 High High
Hepatotoxicity 16 86.00 High High
Depression 1 65.60 Quite High
INFLAMMATION 29 63.32 Quite High
Acidosis 1 63.04 Quite High
Fatty Liver 10 50.00 Quite Low
Injury 9 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Administration of the two compounds (prior to CCl4 injection) significantly increased hepatic vit C content, the most improvement has been achieved by the combination.
Positive_regulation (increased) of Gene_expression (injection) of CCl4
1) Confidence 0.42 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3007612 Disease Relevance 0.22 Pain Relevance 0.03
Lipid accumulation in the liver was confirmed in the CCl4 group, ?
Positive_regulation (confirmed) of Gene_expression (group) of CCl4 in liver
2) Confidence 0.41 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2933434 Disease Relevance 0.15 Pain Relevance 0.06
This protein was also present in the livers of patients with steatosis (a more benign form of liver disease) and in rats with CCl4-induced cirrhosis.
Positive_regulation (induced) of Gene_expression (present) of CCl4 in liver associated with liver disease and cirrhosis
3) Confidence 0.15 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 0.93 Pain Relevance 0

General Comments

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