INT312794

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.63
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pon1) extracellular region (Pon1) lipid metabolic process (Pon1)
Anatomy Link Frequency
liver 2
Hdl1 (Mus musculus)
Pon1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 30 96.96 Very High Very High Very High
alcohol 2 15.76 Low Low
chemokine 2 12.00 Low Low
fibrosis 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 148 100.00 Very High Very High Very High
Stress 20 97.40 Very High Very High Very High
INFLAMMATION 32 96.96 Very High Very High Very High
Liver Disease 28 94.80 High High
Cirrhosis 34 91.36 High High
Hepatotoxicity 4 82.04 Quite High
Hyperlipidemia 2 53.28 Quite High
Targeted Disruption 6 46.00 Quite Low
Atherosclerosis 2 38.24 Quite Low
Splenomegaly 2 29.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of the present study was to investigate the compositional changes in HDL that could influence PON1 activity in liver impairment.


HDL Regulation (influence) of PON1 in liver associated with disorder of lipid metabolism
1) Confidence 0.02 Published 2010 Journal Lipids Health Dis Section Abstract Doc Link PMC2877049 Disease Relevance 0.59 Pain Relevance 0.05
We performed the present study to investigate the lipid and protein changes in HDL particles that could potentially influence PON1 activity and, as well, the effect of these changes on oxidative stress and inflammation in patients with chronic liver impairment.


HDL Regulation (influence) of PON1 in liver associated with stress, inflammation and disorder of lipid metabolism
2) Confidence 0.02 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 1.04 Pain Relevance 0.11

General Comments

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