INT3128

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Context Info
Confidence 0.59
First Reported 1978
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 30
Total Number 33
Disease Relevance 26.19
Pain Relevance 4.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PON1) extracellular region (PON1) lipid metabolic process (PON1)
Anatomy Link Frequency
coronary artery 1
blood 1
erythrocyte 1
spinal cord 1
cleavage 1
PON1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 14 100.00 Very High Very High Very High
Neurotransmitter 10 100.00 Very High Very High Very High
Serotonin 7 100.00 Very High Very High Very High
Spinal cord 6 100.00 Very High Very High Very High
Morphine 19 99.84 Very High Very High Very High
Nicotine 3 98.84 Very High Very High Very High
Inflammation 143 96.80 Very High Very High Very High
Clonidine 6 95.88 Very High Very High Very High
Neuritis 1 95.08 Very High Very High Very High
depression 7 94.88 High High
Disease Link Frequency Relevance Heat
Coronary Artery Disease 29 100.00 Very High Very High Very High
Neuropathy 5 100.00 Very High Very High Very High
Neuropathic Pain 9 99.84 Very High Very High Very High
Systemic Sclerosis 446 99.68 Very High Very High Very High
Cardiovascular Disease 292 99.48 Very High Very High Very High
Targeted Disruption 7 99.48 Very High Very High Very High
Hereditary Angioedema 401 99.22 Very High Very High Very High
Hyperhomocysteinemia 1 99.10 Very High Very High Very High
Systemic Lupus Erythematosus 69 98.92 Very High Very High Very High
Increased Venous Pressure Under Development 229 98.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, various other reports in the medical literature have indicated alterations in serum PON and ARE activities for patients with different rheumatic diseases, such as RA, psoriasis, SLE, and Behcet’s disease.2,12–17 In many of these studies, PON and ARE activities were reported to be significantly lower in patients with rheumatic diseases than in healthy controls.2,12–16 In another study, Kiss and coworkers 16 indicated that ARE activity in patients was not different from that of controls, despite reduced PON activity in patients with SLE.
Negative_regulation (reduced) of PON associated with psoriasis, rheumatoid arthritis, disease, systemic lupus erythematosus and rheumatic diseases
1) Confidence 0.59 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2827704 Disease Relevance 1.38 Pain Relevance 0.46
Earlier studies on the competitive inhibition of human serum esterase by morphine and related compounds were continued.
Negative_regulation (inhibition) of serum esterase associated with morphine
2) Confidence 0.51 Published 1978 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 637624 Disease Relevance 0.07 Pain Relevance 0.14
Animal studies, including PON1-knockout mouse, demonstrated that PON1 deficiency was shown to increase susceptibility to LDL oxidation and atherosclerosis development [8].
Negative_regulation (deficiency) of PON1 associated with targeted disruption and atherosclerosis
3) Confidence 0.42 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2936361 Disease Relevance 1.66 Pain Relevance 0.06
Aslan et al. found decreased serum PON1 activity in H. pylori positive patients [4].
Negative_regulation (decreased) of serum PON1
4) Confidence 0.41 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2936361 Disease Relevance 1.04 Pain Relevance 0
The ApoA1 and PON1 activities were lower in the MCTD/CVD+ and MCTD/CVD- patient groups compared with controls.
Negative_regulation (lower) of PON1 associated with cardiovascular disease and systemic sclerosis
5) Confidence 0.38 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911856 Disease Relevance 2.07 Pain Relevance 0
Decreased PON1 activity and mild elevation in hs-CRP have drawn considerable interest, in relation to the development of atherosclerosis that exemplifies a low-grade chronic inflammatory process [37,38].
Negative_regulation (Decreased) of PON1 associated with inflammation and atherosclerosis
6) Confidence 0.38 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911856 Disease Relevance 1.58 Pain Relevance 0.05
Hereditary angioedema (HAE), a rare genetic disorder caused by a deficiency of the C1 esterase inhibitor, leads to an episodic, self-limiting increase in vascular permeability.
Negative_regulation (deficiency) of esterase associated with hereditary angioedema
7) Confidence 0.38 Published 2008 Journal Eur J Gastroenterol Hepatol Section Abstract Doc Link 18467921 Disease Relevance 0.79 Pain Relevance 0.15
Hereditary angioedema (HAE), a rare genetic disorder caused by a deficiency of the C1 esterase inhibitor, leads to an episodic, self-limiting increase in vascular permeability.
Negative_regulation (inhibitor) of esterase associated with hereditary angioedema
8) Confidence 0.38 Published 2008 Journal Eur J Gastroenterol Hepatol Section Abstract Doc Link 18467921 Disease Relevance 0.80 Pain Relevance 0.15
Previously we described high levels of total serum cholesterol and reduced paraoxonase-1 (PON1) concentrations and activity in patients'sera [13].
Negative_regulation (reduced) of PON1
9) Confidence 0.37 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911856 Disease Relevance 1.19 Pain Relevance 0.05
Although serum PON1 activity in patients with coronary heart disease is decrease and is negatively related to the severity of coronary artery lesions, the correlation between PON1 activity and CIMT is controversial [11,12].
Negative_regulation (decrease) of serum PON1 in coronary artery associated with coronary artery disease
10) Confidence 0.36 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2936361 Disease Relevance 1.37 Pain Relevance 0
In our study we also observed that serum PON1 activity was significantly lower in H. pylori positive subjects when compared with negative subjects.
Negative_regulation (lower) of serum PON1
11) Confidence 0.36 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2936361 Disease Relevance 1.09 Pain Relevance 0
Therefore, reduction of PON1 activity may be considered to be prooxidant and pro-atherogenic (Rainwater et al 2007).
Negative_regulation (reduction) of PON1
12) Confidence 0.33 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663461 Disease Relevance 0.47 Pain Relevance 0
Previously we described high levels of total serum cholesterol and reduced paraoxonase-1 (PON1) concentrations and activity in patients'sera [13].
Negative_regulation (reduced) of paraoxonase-1
13) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911856 Disease Relevance 1.18 Pain Relevance 0.05
Permeation of the ester was assessed with or without the exposure of cells to PMSF, an inhibitor of esterase.
Negative_regulation (inhibitor) of esterase
14) Confidence 0.29 Published 2002 Journal Pharm. Res. Section Body Doc Link 12180533 Disease Relevance 0 Pain Relevance 0
Administration of this organophosphorus ester resulted in > or = 89% inhibition of brain and spinal cord neurotoxic esterase activity in both species 4 hr after dosing.
Negative_regulation (inhibition) of neurotoxic esterase in spinal cord associated with spinal cord
15) Confidence 0.25 Published 1992 Journal Neurotoxicology Section Abstract Doc Link 1302299 Disease Relevance 0.23 Pain Relevance 0.29
Lithium (Li) a specific inhibitor of the enzyme inositol monophosphate esterase reduces the turn over of PIP2 and decreases the cell responses mediated via the cleavage of PIP2. 2.
Negative_regulation (inhibitor) of esterase in cleavage
16) Confidence 0.22 Published 1990 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 2163062 Disease Relevance 0 Pain Relevance 0.24
These findings could support the hypothesis that some of the action of Li in humans is mediated through the inhibition of the enzyme inositol monophosphate esterase.
Negative_regulation (inhibition) of esterase
17) Confidence 0.22 Published 1990 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 2163062 Disease Relevance 0 Pain Relevance 0.24
Inositol monophosphate esterase inhibition by lithium in normal human studies using neuroendocrine tests.
Negative_regulation (inhibition) of esterase
18) Confidence 0.22 Published 1990 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Title Doc Link 2163062 Disease Relevance 0 Pain Relevance 0.25
Galantamine binds allosteric sites of nicotine receptor and stimulates it in addition to its inhibitory effect on ACh esterase.
Negative_regulation (effect) of ACh esterase associated with nicotine
19) Confidence 0.21 Published 2002 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 12491771 Disease Relevance 0.91 Pain Relevance 0.22
In addition, activities of neuropathy target esterase and acetylcholinesterase were significantly reduced after exposure to 5 mM TOCP for 12 hr.
Negative_regulation (reduced) of esterase associated with neuropathic pain
20) Confidence 0.13 Published 2006 Journal Mol. Cell. Biochem. Section Abstract Doc Link 16909309 Disease Relevance 0.34 Pain Relevance 0.10

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