INT312813

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Context Info
Confidence 0.01
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.26
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Tpsab1) signal transduction (F2rl1) extracellular region (Tpsab1)
plasma membrane (F2rl1) signal transducer activity (F2rl1)
Anatomy Link Frequency
neurons 1
F2rl1 (Mus musculus)
Tpsab1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 3 97.92 Very High Very High Very High
Hyperalgesia 1 94.32 High High
Inflammation 40 92.72 High High
substance P 35 89.68 High High
Central nervous system 4 78.64 Quite High
cytokine 12 70.68 Quite High
Nerve growth factor 19 52.80 Quite High
qutenza 4 41.96 Quite Low
c fibre 3 41.44 Quite Low
Neuropeptide 27 19.04 Low Low
Disease Link Frequency Relevance Heat
Hyperalgesia 1 94.32 High High
INFLAMMATION 35 92.72 High High
Disease 5 15.60 Low Low
Hypersensitivity 4 15.24 Low Low
Bacterial Infection 1 13.88 Low Low
Stress 13 5.00 Very Low Very Low Very Low
Neurogenic Inflammation 8 5.00 Very Low Very Low Very Low
Infection 6 5.00 Very Low Very Low Very Low
Asthma 4 5.00 Very Low Very Low Very Low
Anaphylaxis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They hypothesized that tryptase excites neurons through PAR2 because activation of PAR2 with trypsin or peptide agonists strongly desensitizes the response to tryptase.
PAR2 Binding (excites) of tryptase in neurons associated with agonist
1) Confidence 0.01 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 0.26 Pain Relevance 0.46

General Comments

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