INT312821

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Context Info
Confidence 0.37
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.13
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins2) extracellular region (Ins2) nucleus (Ins2)
carbohydrate metabolic process (Ins2) cytoplasm (Ins2)
Anatomy Link Frequency
heart 1
Ins2 (Mus musculus)
Pain Link Frequency Relevance Heat
diabetic neuropathy 53 98.36 Very High Very High Very High
analgesia 1 96.12 Very High Very High Very High
Neuropathic pain 3 91.04 High High
Nicotine 2 85.96 High High
tolerance 26 71.44 Quite High
Sciatic nerve 21 48.96 Quite Low
sodium channel 5 7.52 Low Low
alcohol 10 5.00 Very Low Very Low Very Low
Action potential 3 5.00 Very Low Very Low Very Low
beta blocker 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 83 98.76 Very High Very High Very High
Peripheral Neuropathy 53 98.36 Very High Very High Very High
Cardiovascular Disease 2 95.48 Very High Very High Very High
Neuropathic Pain 7 91.04 High High
Hypesthesia 1 88.36 High High
Injury 2 87.96 High High
Nicotine Addiction 16 86.76 High High
Disease 3 85.96 High High
Hyperinsulinism 4 77.84 Quite High
Impaired Glucose Tolerance 26 72.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overall, our phenotypic characterization of Ins2Akita/+ mice suggests that these mice develop DPN rapidly after the onset of diabetes and thus represent an interesting model of some of the DPN symptoms observed in patients which often present simultaneously positive (burning, neuropathic pain, abnormal sensation to temperature) and negative (numbness, injury insensitivity) sensory findings [4], [29].


Ins2Akita Binding (characterization) of associated with hypesthesia, diabetes mellitus, diabetic neuropathy, injury and neuropathic pain
1) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877074 Disease Relevance 1.21 Pain Relevance 0.38
Higher log10(insulin) and log10(proinsulin) were also associated with increased waist circumferences and log10(?
proinsulin Binding (associated) of
2) Confidence 0.26 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC3020169 Disease Relevance 0.29 Pain Relevance 0
Elevated heart rate may reflect a shift in autonomic balance toward enhanced sympathetic tone [43] and is associated with higher insulin [44] and proinsulin concentrations [45], as also observed in the present study.
proinsulin Binding (associated) of in heart
3) Confidence 0.25 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC3020169 Disease Relevance 0.62 Pain Relevance 0.08

General Comments

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