INT312829

Context Info Confidence 0.50 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.73 Pain Relevance 0.40

extracellular space (Ins2) extracellular region (Ins2) nucleus (Ins2) carbohydrate metabolic process (Ins2) cytoplasm (Ins2)

Ins2 (Mus musculus)

Pain Link Frequency Relevance Heat diabetic neuropathy 106 76.24 Sciatic nerve 42 18.36 sodium channel 10 5.00 Neuropathic pain 6 5.00 Action potential 6 5.00 Nav1.6 2 5.00 hyperexcitability 2 5.00 analgesia 2 5.00 Kinase C 2 5.00 nav1.3 2 5.00

Disease Link Frequency Relevance Heat Apoptosis 2 98.24 Diabetes Mellitus 78 86.40 Hyperglycemia 40 84.32 Peripheral Neuropathy 106 76.24 Diabetic Neuropathy 2 50.00 Neuropathic Pain 14 5.00 Congenital Anomalies 6 5.00 Disease 6 5.00 Injury 4 5.00 Demyelinating Disease 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A recent report suggested that the intracellular accumulation of the misfolded Proinsulin 2 leads to progressive disruption of the insulin secretory pathway organelle architecture and thereby resulting in pancreatic ?

Positive_regulation (leads) of Positive_regulation (accumulation) of Proinsulin

1) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877074 Disease Relevance 0.85 Pain Relevance 0.20

A recent report suggested that the intracellular accumulation of the misfolded Proinsulin 2 leads to progressive disruption of the insulin secretory pathway organelle architecture and thereby resulting in pancreatic ?

Positive_regulation (resulting) of Positive_regulation (accumulation) of Proinsulin

2) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877074 Disease Relevance 0.89 Pain Relevance 0.21

General Comments

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