INT312831

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.13
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.46
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Lck) plasma membrane (Lck) kinase activity (Lck)
cytoplasm (Lck)
Anatomy Link Frequency
sensory nerve 1
thoracic 1
Lck (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 1 98.84 Very High Very High Very High
Sciatic nerve 42 98.64 Very High Very High Very High
diabetic neuropathy 106 97.64 Very High Very High Very High
cytokine 1 83.96 Quite High
corticosteroid 2 60.60 Quite High
sodium channel 10 5.00 Very Low Very Low Very Low
Central nervous system 7 5.00 Very Low Very Low Very Low
Neuropathic pain 6 5.00 Very Low Very Low Very Low
Action potential 6 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperglycemia 40 100.00 Very High Very High Very High
Rheumatoid Arthritis 1 98.84 Very High Very High Very High
Autoimmune Disease 2 98.04 Very High Very High Very High
Disease 13 97.88 Very High Very High Very High
Peripheral Neuropathy 106 97.64 Very High Very High Very High
Immune System Diseases 1 96.52 Very High Very High Very High
Opportunistic Infections 1 91.32 High High
Apoptosis 4 86.88 High High
Fever 3 85.00 Quite High
Arthralgia 1 84.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, dasatinib-induced Lck inhibition has also been implicated in the pathogenesis of autoimmune disorders in two recent case reports.49,55 In the first case, the patient presented with respiratory symptoms, diffuse ground glass opacities on thoracic high-resolution computer tomography and appearance of antinuclear and anti-DNA antibodies after 29 days of treatment with dasatinib.49 The second case developed fever, arthralgia, pleural effusion, pericardial effusion and autoantibodies after 6 months of dasatinib therapy, suggesting a possibility of dasatinib-induced lupus.55 In both cases, the autoantibodies were not present before dasatinib.
Negative_regulation (inhibition) of Lck in thoracic associated with pleural effusion, pressure and volume under development, arthralgia, autoimmune disease, systemic lupus erythematosus and fever
1) Confidence 0.13 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886328 Disease Relevance 1.40 Pain Relevance 0.12
In the set of animals used for microarray experiments, increased glycemia was initially observed at P24 and hyperglycemia became clear at P28, followed by a small decrease in weight at P48 and P56.
Negative_regulation (decrease) of P56 associated with hyperglycemia
2) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877074 Disease Relevance 0.22 Pain Relevance 0.08
We observed a decrease in MNCV already one week after the onset of hyperglycemia and a decrease in SNCV at P56, one month after the onset of hyperglycemia, indicating that DPN affects both motor and sensory nerve fibers.
Negative_regulation (decrease) of P56 in sensory nerve associated with hyperglycemia and diabetic neuropathy
3) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877074 Disease Relevance 0.84 Pain Relevance 0.15

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox