INT312879

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Context Info
Confidence 0.55
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0.76
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hdac6) nucleolus (Hdac6) nucleus (Hdac6)
intracellular (Hdac6) protein complex (Hdac6) cytoplasm (Hdac6)
Anatomy Link Frequency
neurons 2
Hdac6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 6 96.76 Very High Very High Very High
Serotonin 12 95.92 Very High Very High Very High
fluoxetine 18 91.80 High High
sSRI 12 91.32 High High
cerebral cortex 6 52.80 Quite High
Hippocampus 6 51.20 Quite High
agonist 12 25.00 Low Low
imagery 30 11.36 Low Low
Disease Link Frequency Relevance Heat
Depression 6 96.76 Very High Very High Very High
Disease 84 80.64 Quite High
Stress 6 79.68 Quite High
Targeted Disruption 6 70.64 Quite High
Neurodegenerative Disease 12 69.52 Quite High
Infection 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
would directly affect HDAC6 activity.
Regulation (affect) of HDAC6
1) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0
The regulation of HDAC6 would affect intracellular trafficking of both organelles and proteins in neurons through changes in levels of acetylated tubulin.
Regulation (regulation) of HDAC6 in neurons
2) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0.33 Pain Relevance 0.24
signaling pathway may control mitochondrial movement in neurons by modulating acetylation of microtubules via the regulation of HDAC6.


Regulation (regulation) of HDAC6 in neurons
3) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0
Microtubule-dependent intracellular trafficking may therefore be regulated by modulating the activity of HDAC6.
Regulation (modulating) of HDAC6
4) Confidence 0.24 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0.05
likely regulates HDAC6 activity, suggests that HDAC6 is a substrate for GSK3?.
Regulation (regulates) of HDAC6
5) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0
may directly regulate HDAC6.


Spec (may) Regulation (regulate) of HDAC6
6) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0.44 Pain Relevance 0

General Comments

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