INT312879

Context Info Confidence 0.55 First Reported 2010 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 6 Disease Relevance 0.76 Pain Relevance 0.29

cytosol (Hdac6) nucleolus (Hdac6) nucleus (Hdac6) intracellular (Hdac6) protein complex (Hdac6) cytoplasm (Hdac6)

Anatomy Link Frequency neurons 2 Hdac6 (Rattus norvegicus)

Pain Link Frequency Relevance Heat depression 6 96.76 Serotonin 12 95.92 fluoxetine 18 91.80 sSRI 12 91.32 cerebral cortex 6 52.80 Hippocampus 6 51.20 agonist 12 25.00 imagery 30 11.36

Disease Link Frequency Relevance Heat Depression 6 96.76 Disease 84 80.64 Stress 6 79.68 Targeted Disruption 6 70.64 Neurodegenerative Disease 12 69.52 Infection 12 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

would directly affect HDAC6 activity.

Regulation (affect) of HDAC6

1) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0

The regulation of HDAC6 would affect intracellular trafficking of both organelles and proteins in neurons through changes in levels of acetylated tubulin.

Regulation (regulation) of HDAC6 in neurons

2) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0.33 Pain Relevance 0.24

signaling pathway may control mitochondrial movement in neurons by modulating acetylation of microtubules via the regulation of HDAC6.

Regulation (regulation) of HDAC6 in neurons

3) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0

Microtubule-dependent intracellular trafficking may therefore be regulated by modulating the activity of HDAC6.

Regulation (modulating) of HDAC6

4) Confidence 0.24 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0.05

likely regulates HDAC6 activity, suggests that HDAC6 is a substrate for GSK3?.

Regulation (regulates) of HDAC6

5) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0

may directly regulate HDAC6.

Spec (may) Regulation (regulate) of HDAC6

6) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0.44 Pain Relevance 0

General Comments

This test has worked.