INT312881

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Context Info
Confidence 0.45
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.67
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hdac6) nucleolus (Hdac6) nucleus (Hdac6)
intracellular (Hdac6) protein complex (Hdac6) cytoplasm (Hdac6)
Anatomy Link Frequency
neurons 1
Hdac6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 3 83.52 Quite High
cerebral cortex 3 82.88 Quite High
Serotonin 6 81.76 Quite High
depression 3 54.68 Quite High
fluoxetine 9 49.72 Quite Low
sSRI 6 49.24 Quite Low
imagery 15 45.84 Quite Low
agonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 42 99.66 Very High Very High Very High
Stress 3 69.08 Quite High
Infection 6 59.44 Quite High
Depression 3 54.68 Quite High
Targeted Disruption 3 28.56 Quite Low
Neurodegenerative Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-dependent phosphorylation may enhance HDAC6 activity, resulting in a decrease in acetylation of tubulin and an inhibition of both mitochondrial motility and the transport of other kinesin-1 dependent cargoes.
Spec (may) Positive_regulation (enhance) of HDAC6
1) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0.04
activity was elevated by inhibiting Akt (Akt inhibitor VIII, 5 ┬ÁM), the activity of HDAC6 was significantly increased (Fig. 4D), a finding that is consistent with the Western blot analysis of tubulin acetylation in hippocampal neurons shown in Figure 3I and J.


Positive_regulation (increased) of HDAC6 in neurons
2) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0
Given these observations, it is possible that the reported perturbation of mitochondrial transport associated with Alzheimer's disease is caused by an elevated level of HDAC6 and a consequent alteration of the cellular trafficking machinery.
Positive_regulation (elevated) of HDAC6 associated with disease
3) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0.67 Pain Relevance 0.11

General Comments

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