INT312881
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
-dependent phosphorylation may enhance HDAC6 activity, resulting in a decrease in acetylation of tubulin and an inhibition of both mitochondrial motility and the transport of other kinesin-1 dependent cargoes. | |||||||||||||||
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activity was elevated by inhibiting Akt (Akt inhibitor VIII, 5 µM), the activity of HDAC6 was significantly increased (Fig. 4D), a finding that is consistent with the Western blot analysis of tubulin acetylation in hippocampal neurons shown in Figure 3I and J.
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Given these observations, it is possible that the reported perturbation of mitochondrial transport associated with Alzheimer's disease is caused by an elevated level of HDAC6 and a consequent alteration of the cellular trafficking machinery. | |||||||||||||||
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General Comments
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