INT312881

Context Info Confidence 0.45 First Reported 2010 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0.67 Pain Relevance 0.15

cytosol (Hdac6) nucleolus (Hdac6) nucleus (Hdac6) intracellular (Hdac6) protein complex (Hdac6) cytoplasm (Hdac6)

Anatomy Link Frequency neurons 1 Hdac6 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Hippocampus 3 83.52 cerebral cortex 3 82.88 Serotonin 6 81.76 depression 3 54.68 fluoxetine 9 49.72 sSRI 6 49.24 imagery 15 45.84 agonist 6 5.00

Disease Link Frequency Relevance Heat Disease 42 99.66 Stress 3 69.08 Infection 6 59.44 Depression 3 54.68 Targeted Disruption 3 28.56 Neurodegenerative Disease 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

-dependent phosphorylation may enhance HDAC6 activity, resulting in a decrease in acetylation of tubulin and an inhibition of both mitochondrial motility and the transport of other kinesin-1 dependent cargoes.

Spec (may) Positive_regulation (enhance) of HDAC6

1) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0.04

activity was elevated by inhibiting Akt (Akt inhibitor VIII, 5 µM), the activity of HDAC6 was significantly increased (Fig. 4D), a finding that is consistent with the Western blot analysis of tubulin acetylation in hippocampal neurons shown in Figure 3I and J.

Positive_regulation (increased) of HDAC6 in neurons

2) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0

Given these observations, it is possible that the reported perturbation of mitochondrial transport associated with Alzheimer's disease is caused by an elevated level of HDAC6 and a consequent alteration of the cellular trafficking machinery.

Positive_regulation (elevated) of HDAC6 associated with disease

3) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0.67 Pain Relevance 0.11

General Comments

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