INT312882

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.52
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 19
Disease Relevance 1.86
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hdac6) nucleolus (Hdac6) nucleus (Hdac6)
intracellular (Hdac6) protein complex (Hdac6) cytoplasm (Hdac6)
Anatomy Link Frequency
neurons 5
Brain 1
Hdac6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
imagery 95 95.32 Very High Very High Very High
sSRI 38 90.92 High High
Serotonin 38 90.36 High High
fluoxetine 57 89.24 High High
depression 19 70.48 Quite High
agonist 38 66.24 Quite High
cerebral cortex 19 14.48 Low Low
Hippocampus 19 12.88 Low Low
Disease Link Frequency Relevance Heat
Disease 266 98.00 Very High Very High Very High
Targeted Disruption 19 89.84 High High
Neurodegenerative Disease 38 86.60 High High
Depression 19 70.48 Quite High
Stress 19 41.36 Quite Low
Infection 38 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that the presence of tubacin, a specific HDAC6 inhibitor, dramatically enhanced mitochondrial movement in hippocampal neurons, whereas niltubacin, an inactive tubacin analog, had no effect.
Negative_regulation (inhibitor) of HDAC6 in neurons
1) Confidence 0.52 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0.05
inhibitors resulted in a slight decrease of HDAC6 protein level (Fig. 4A, B).
Negative_regulation (decrease) of HDAC6
2) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0
Consistent with this idea, it was recently reported that inhibition of HDAC6 produced a higher transfection efficiency by enhancing intracellular transport of transfected plasmids [22].


Negative_regulation (inhibition) of HDAC6
3) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0
Inhibition of HDAC6 increases acetylation of tubulin and association of kinesin-1 with mitochondria in hippocampal neurons
Negative_regulation (Inhibition) of HDAC6 in neurons
4) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0.05
Inhibition of HDAC6 results in higher levels of acetylated tubulin and enhanced binding of the motor protein kinesin-1 to tubulin, which promotes transport of cargoes along microtubules.
Negative_regulation (Inhibition) of HDAC6
5) Confidence 0.52 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0.04
In the present study, we show that specific inhibition of HDAC6 greatly enhances mitochondrial trafficking in cultured hippocampal neurons.
Negative_regulation (inhibition) of HDAC6 in neurons
6) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0.60 Pain Relevance 0
Inhibition of HDAC6 by tubacin greatly increases mitochondrial movement
Negative_regulation (Inhibition) of HDAC6
7) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0.43 Pain Relevance 0
As shown by Western blot analysis, inhibition of HDAC6 by tubacin increased the amount of kinesin-1 associated with mitochondria compared to an untreated control (Fig. 2E, lanes 1 and 2).
Negative_regulation (inhibition) of HDAC6
8) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0.03
Here, we demonstrate that inhibition of HDAC6 affects mitochondrial trafficking in a manner similar to that of GSK3?
Negative_regulation (inhibition) of HDAC6
9) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0.47 Pain Relevance 0
We suggest that 5-HT promotes axonal transport of mitochondria in a manner similar to that of HDAC6 inhibition.
Negative_regulation (inhibition) of HDAC6
10) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0.17
These results closely resemble the effects of inhibiting HDAC6 using tubacin or TSA (Fig. 2A, lanes 2 and 3; Fig. 2E, lanes 2 and 3).
Negative_regulation (inhibiting) of HDAC6
11) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0
Moreover, Dompierre et al. [5] found that inhibiting HDAC6 reversed the transport deficit in a Huntington's disease model by increasing the vesicular transport of Brain-Derived Neurotrophic Factor (BDNF), another kinesin-1 cargo protein.
Negative_regulation (inhibiting) of HDAC6 in Brain associated with disease
12) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0.10 Pain Relevance 0
inhibition and HDAC6 activity are closely linked.
Negative_regulation (inhibition) of HDAC6
13) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0.26 Pain Relevance 0.16
Specific inhibition of HDAC6 leads to increased mitochondrial motility
Negative_regulation (inhibition) of HDAC6
14) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0.10
Since kinesin-1 is not an exclusively mitochondrial motor protein, it is likely that the observed effect of increased acetylation of microtubules on mitochondrial movement produced by inhibiting HDAC6 is a reflection of a more general promotion of intracellular cytoplasmic trafficking within neurons.
Negative_regulation (inhibiting) of HDAC6 in neurons
15) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0
decreases the activity and protein levels of HDAC6 in hippocampal neurons
Negative_regulation (decreases) of HDAC6 in neurons
16) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0
In contrast, niltubacin (20 ┬ÁM), a tubacin analog that neither inhibits HDAC6 nor enhances acetylation of microtubules [14], did not alter mitochondrial movement (Fig. 1C, F, I and Movies S7, S8, S9).
Negative_regulation (inhibits) of HDAC6
17) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0.04
This was demonstrated by preventing tubulin deacetylation with tubacin, a specific HDAC6 inhibitor.
Negative_regulation (inhibitor) of HDAC6
18) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0
Under pathological circumstances, the effect of HDAC6 on the degradation of misfolded-protein may also be involved in mitochondrial trafficking.
Negative_regulation (effect) of HDAC6
19) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox