INT312883

Context Info Confidence 0.40 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.38 Pain Relevance 0.24

cytosol (Hdac6) nucleolus (Hdac6) nucleus (Hdac6) intracellular (Hdac6) protein complex (Hdac6) cytoplasm (Hdac6)

Anatomy Link Frequency neurons 2 Hdac6 (Rattus norvegicus)

Pain Link Frequency Relevance Heat depression 1 96.76 fluoxetine 3 91.80 sSRI 2 91.32 cerebral cortex 1 53.84 Hippocampus 1 52.24 Serotonin 2 24.24 imagery 5 5.00 agonist 2 5.00

Disease Link Frequency Relevance Heat Depression 1 96.76 Stress 1 80.72 Disease 14 78.76 Targeted Disruption 1 70.64 Neurodegenerative Disease 2 5.00 Infection 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The regulation of HDAC6 would affect intracellular trafficking of both organelles and proteins in neurons through changes in levels of acetylated tubulin.

Regulation (affect) of Regulation (regulation) of HDAC6 in neurons

1) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0.38 Pain Relevance 0.24

General Comments

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