INT312885

Context Info Confidence 0.43 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0 Pain Relevance 0

cytosol (Hdac6) nucleolus (Hdac6) nucleus (Hdac6) intracellular (Hdac6) protein complex (Hdac6) cytoplasm (Hdac6)

Anatomy Link Frequency neuronal 1 neurons 1 Hdac6 (Rattus norvegicus)

Pain Link Frequency Relevance Heat imagery 10 5.00 fluoxetine 6 5.00 sSRI 4 5.00 agonist 4 5.00 Serotonin 4 5.00 cerebral cortex 2 5.00 depression 2 5.00 Hippocampus 2 5.00

Disease Link Frequency Relevance Heat Disease 28 5.00 Neurodegenerative Disease 4 5.00 Infection 4 5.00 Depression 2 5.00 Stress 2 5.00 Targeted Disruption 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Moreover, the cdc20-APC aggresome complex was also shown to be involved in direct binding to HDAC6, as well as neuronal dendritic morphogenesis [26].

HDAC6 Binding (binding) of in neuronal

1) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0

Since kinesin-1 is not an exclusively mitochondrial motor protein, it is likely that the observed effect of increased acetylation of microtubules on mitochondrial movement produced by inhibiting HDAC6 is a reflection of a more general promotion of intracellular cytoplasmic trafficking within neurons.

HDAC6 Binding (inhibiting) of in neurons

2) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0

General Comments

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