INT312887

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Context Info
Confidence 0.60
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.28
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hdac6) nucleolus (Hdac6) nucleus (Hdac6)
intracellular (Hdac6) protein complex (Hdac6) cytoplasm (Hdac6)
Anatomy Link Frequency
neurons 3
Hdac6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 5 77.68 Quite High
cerebral cortex 5 77.04 Quite High
Serotonin 10 72.24 Quite High
imagery 25 57.36 Quite High
depression 5 48.84 Quite Low
fluoxetine 15 43.88 Quite Low
sSRI 10 43.40 Quite Low
agonist 10 22.72 Low Low
Disease Link Frequency Relevance Heat
Disease 70 99.96 Very High Very High Very High
Infection 10 70.96 Quite High
Stress 5 63.24 Quite High
Depression 5 48.84 Quite Low
Targeted Disruption 5 22.72 Low Low
Neurodegenerative Disease 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, it is possible that, in Alzheimer's disease, aberrant HDAC6 levels are induced by increased activity of GSK3?
Gene_expression (aberrant) of HDAC6 associated with disease
1) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0.64 Pain Relevance 0.11
were found in the same protein complex in hippocampal neurons (Fig. 5G), suggesting that HDAC6 and GSK3?
Gene_expression (suggesting) of HDAC6 in neurons
2) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0
Moreover, it is possible that, in Alzheimer's disease, aberrant HDAC6 levels are induced by increased activity of GSK3?
Gene_expression (levels) of HDAC6 associated with disease
3) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0.64 Pain Relevance 0.11
decreases the activity and protein levels of HDAC6 in hippocampal neurons
Gene_expression (levels) of HDAC6 in neurons
4) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0
The fact that HDAC6 is the predominant cytoplasmic deacetylase in neurons [1] suggests that GSK3?
Gene_expression (is) of HDAC6 in neurons
5) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0.04

General Comments

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