INT312887

Context Info Confidence 0.60 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 5 Disease Relevance 1.28 Pain Relevance 0.25

cytosol (Hdac6) nucleolus (Hdac6) nucleus (Hdac6) intracellular (Hdac6) protein complex (Hdac6) cytoplasm (Hdac6)

Anatomy Link Frequency neurons 3 Hdac6 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Hippocampus 5 77.68 cerebral cortex 5 77.04 Serotonin 10 72.24 imagery 25 57.36 depression 5 48.84 fluoxetine 15 43.88 sSRI 10 43.40 agonist 10 22.72

Disease Link Frequency Relevance Heat Disease 70 99.96 Infection 10 70.96 Stress 5 63.24 Depression 5 48.84 Targeted Disruption 5 22.72 Neurodegenerative Disease 10 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Moreover, it is possible that, in Alzheimer's disease, aberrant HDAC6 levels are induced by increased activity of GSK3?

Gene_expression (aberrant) of HDAC6 associated with disease

1) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0.64 Pain Relevance 0.11

were found in the same protein complex in hippocampal neurons (Fig. 5G), suggesting that HDAC6 and GSK3?

Gene_expression (suggesting) of HDAC6 in neurons

2) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0

Moreover, it is possible that, in Alzheimer's disease, aberrant HDAC6 levels are induced by increased activity of GSK3?

Gene_expression (levels) of HDAC6 associated with disease

3) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0.64 Pain Relevance 0.11

decreases the activity and protein levels of HDAC6 in hippocampal neurons

Gene_expression (levels) of HDAC6 in neurons

4) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0

The fact that HDAC6 is the predominant cytoplasmic deacetylase in neurons [1] suggests that GSK3?

Gene_expression (is) of HDAC6 in neurons

5) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877100 Disease Relevance 0 Pain Relevance 0.04

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